- PO (Adults ): 250–500 mg q 6 hr or 500 mg–1 g q 12 hr. Chronic treatment of acne: 500 mg–2 g/day for 3 wk, then ↓ to 125 mg–1 g/day.
- PO (Children ≥8 yr): 6.25–12.5 mg/kg q 6 hr or 12.5–25 mg/kg q 12 hr.
REMS
Contraindicated in:
Use Cautiously in:
Derm: photosensitivity, rashes
GI: diarrhea, nausea, vomiting, esophagitis, hepatotoxicity, pancreatitis
Hemat: blood dyscrasias
Neuro: dizziness, intracranial hypertension
Misc: hypersensitivity reactions, superinfection
Drug-drug:
Drug-Food:
Spectrum:
Absorption: 60–80% absorbed after oral administration.
Distribution: Widely distributed, some CSF and good bone penetration; crosses the placenta and enters breast milk.
Half-Life: 6–12 hr.
NDC Code
