- Either tablets or powder for oral solution can be used for refractory complex partial seizures; only powder for oral solution or oral solution should be used for infantile spasms.
Refractory Complex Partial Seizures
- PO (Adults and Children ≥17 yr): 500 mg twice daily initially; may ↑ in 500-mg increments every 7 days, depending on response, up to 1500 mg twice daily.
- PO (Children 2–16 yr and >60 kg): 500 mg twice daily initially; may ↑ in 500-mg increments every 7 days, depending on response, up to 1500 mg twice daily.
- PO (Children 2–16 yr and 26–60 kg): 250 mg twice daily initially; may ↑ every 7 days, depending on response, up to 1000 mg twice daily.
- PO (Children 2–16 yr and 21–25 kg): 250 mg twice daily initially; may ↑ every 7 days, depending on response, up to 750 mg twice daily.
- PO (Children 2–16 yr and 16–20 kg): 225 mg twice daily initially; may ↑ every 7 days, depending on response, up to 650 mg twice daily.
- PO (Children 2–16 yr and 10–15 kg): 175 mg twice daily initially; may ↑ every 7 days, depending on response, up to 525 mg twice daily.
Renal Impairment
- PO (Adults and Children ≥2 yr and ≥10 kg): CCr >50–80 mL/min: ↓dose by 25%; CCr >30–50 mL/min: ↓dose by 50%; CCr >10–30 mL/min: ↓dose by 75%.
Infantile Spasms
- PO (Children 1 mo–2 yr): 25 mg/kg twice daily initially; may be ↑ by 25–50 mg/kg/day increments every 3 days up to a maximum of 150 mg/kg/day (75 mg/kg twice daily); dosage adjustments are necessary for renal impairment.
Therapeutic Classification: anticonvulsants
Absorption: Completely absorbed following oral administration.
Distribution: Widely distributed to tissues.
Metabolism/Excretion: Minimal metabolism, mostly eliminated unchanged in urine.
Half-Life: 7.5 hr.
