- Children ≤12 yr should not receive >5 PO or rectal doses/24 hr without notifying physician or other health care professional. No dose adjustment needed when converting between IV and PO acetaminophen in adults and children ≥50 kg
- PO (Adults and Children >12 yr): 325–650 mg every 6 hr or 1 g 3–4 times daily or 1300 mg every 8 hr (not to exceed 3 g or 2 g/24 hr in patients with hepatic/renal impairment).
- PO (Children 1–12 yr): 10–15 mg/kg/dose every 6 hr as needed (not to exceed 5 doses/24 hr).
- PO (Infants ): 10–15 mg/kg/dose every 6 hr as needed (not to exceed 5 doses/24 hr).
- PO (Neonates ): 10–15 mg/kg/dose every 6–8 hr as needed.
- IV (Adults and Children ≥13 yr and ≥50 kg): 1000 mg every 6 hr or 650 mg every 4 hr (not to exceed 1000 mg/dose, 4 g/day [by all routes], and less than 4 hr dosing interval).
- IV (Adults and Children ≥13 yr and <50 kg): 15 mg/kg every 6 hr or 12.5 mg/kg every 4 hr (not to exceed 15 mg/kg/dose [up to 750 mg/dose], 75 mg/kg/day [up to 3750 mg/day] [by all routes], and less than 4 hr dosing interval).
- IV (Children 2–12 yr): 15 mg/kg every 6 hr or 12.5 mg/kg every 4 hr (not to exceed 15 mg/kg/dose [up to 750 mg/dose], 75 mg/kg/day [up to 3750 mg/day] [by all routes], and less than 4 hr dosing interval).
- IV (Infants 29 days–2 yr): 15 mg/kg every 6 hr (not to exceed 60 mg/kg/day [by all routes]).
- IV (Neonates Birth–28 days): 12.5 mg/kg every 6 hr (not to exceed 50 mg/kg [by all routes]).
- Rect (Adults and Children >12 yr): 325–650 mg every 4–6 hr as needed or 1 g 3–4 times/day (not to exceed 4 g/24 hr).
- Rect (Children 1–12 yr): 10–20 mg/kg/dose every 4–6 hr as needed.
- Rect (Infants ): 10–20 mg/kg/dose every 4–6 hr as needed.
- Rect (Neonates ): 10–15 mg/kg/dose every 6–8 hr as needed.
