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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: flushing, pruritus, rash, STEVENS-JOHNSON SYNDROME (SJS), TOXIC EPIDERMAL NECROLYSIS (TEN)

GI: ↑liver enzymes, diarrhea, nausea, vomiting

GU: ↑serum creatinine

Local: venous irritation at injection site

Neuro: headache

Resp: bronchospasm

Misc: chills, fever, HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA)

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Hepatic Impairment

US Brand Names ⬆ ⬇

Cancidas

Action ⬆ ⬇

  • Inhibits the synthesis of (1, 3)-D-glucan, a necessary component of the fungal cell wall.
Therapeutic effects:
  • Death of susceptible fungi.

Classifications ⬆ ⬇

Therapeutic Classification: antifungals

Pharmacologic Classification: echinocandins

Pharmacokinetics ⬆ ⬇

Absorption: IV administration results in complete bioavailability.

Distribution: Widely distributed to tissues.

Protein Binding: 97%.

Metabolism/Excretion: Slowly and extensively metabolized; <1.5% excreted unchanged in urine.

Half-Life: Polyphasic: phase: 9–11 hr; phase: 40–50 hr.

Time/Action Profile ⬆ ⬇

ROUTEONSETPEAKDURATION
IVunknownend of infusion24 hr

Patient/Family Teaching ⬆ ⬇

  • Explain purpose and side effects of medication to patient. Advise patient to read Patient Information before starting therapy. Inform patient about the need for routine lab monitoring during therapy.
  • Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult health care professional before taking other medications.
  • Advise patient to notify health care professional immediately if symptoms of allergic reactions (rash, facial swelling, pruritus, sensation of warmth, difficulty breathing) occur.
  • Rep: Advise women of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Pronunciation ⬆ ⬇

kas-po-FUN-gin

Code ⬆

NDC Code