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Indications ⬇

REMS

Unlabeled Use:
  • Treatment of Lyme disease.
  • Prevention of recurrent Streptococcal pneumoniae septicemia in children with sickle-cell disease.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: rash, urticaria

GI: diarrhea, epigastric distress, nausea, vomiting, Clostridioides difficile-associated diarrhea (CDAD)

GU: interstitial nephritis

Hemat: eosinophilia, leukopenia

Neuro: SEIZURES

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND SERUM SICKNESS) , superinfection

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Action ⬆ ⬇

  • Bind to bacterial cell wall, resulting in cell death.
Therapeutic effects:
  • Bactericidal action against susceptible bacteria.

Spectrum:

Classifications ⬆ ⬇

Therapeutic Classification: anti-infectives

Pharmacologic Classification: penicillins

Pharmacokinetics ⬆ ⬇

Absorption: Variably absorbed from the GI tract. Resists acid degradation in the GI tract.

Distribution: Widely distributed, although CNS penetration is poor in the presence of normal (non-inflamed) meninges. Crosses the placenta and enters breast milk.

Protein Binding: 60%.

Metabolism/Excretion: Minimally metabolized by the liver, excreted mainly unchanged by the kidneys.

Half-Life: 30–60 min.

Canadian Brand Names ⬆ ⬇

Pen VK

Time/Action Profile ⬆ ⬇

(blood levels)

ROUTEONSETPEAKDURATION
POrapid0.5–1 hr4–6 hr

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

pen-i-SILL-in vee

Code ⬆

NDC Code