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Indications ⬇

BEERS REMS

Amrix and FexmidTonmya

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: arrhythmias

EENT: dry mouth, blurred vision

GI: oral hypoesthesia (SL), constipation, dry mouth (SL), dyspepsia, nausea, oral lesions (SL), oral pain (SL), oral paresthesia (SL), unpleasant taste

GU: urinary retention

Neuro: dizziness, drowsiness, confusion, fatigue, headache, nervousness

Interactions ⬆ ⬇

Drug-drug:

Drug-Natural Products:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Acute Painful Musculoskeletal Conditions Associated with Muscle Spasm (Amrix and Fexmid)

Fibromyalgia (Tonmya)

Hepatic Impairment

US Brand Names ⬆ ⬇

Amrix, Fexmid, Flexeril, Tonmya

Action ⬆ ⬇

  • Reduces tonic somatic muscle activity at the level of the brain stem. Structurally similar to tricyclic antidepressants.
Therapeutic effects:
  • Reduction in muscle spasm and hyperactivity without loss of function.
  • Reduction in pain associated with fibromyalgia.

Classifications ⬆ ⬇

Therapeutic Classification: skeletal muscle relaxants ((centrally acting)

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed from the GI tract following oral administration. Extent of absorption associated with SL administration unknown.

Distribution: Unknown.

Protein Binding: 93%.

Metabolism/Excretion: Primarily metabolized by the liver by CYP3A4 and CYP1A2, and to a lesser extent by CYP2D6. Metabolites primarily excreted by kidneys.

Half-Life: 1–3 days.

Time/Action Profile ⬆ ⬇

( skeletal muscle relaxation)

ROUTEONSETPEAK‡DURATION
POwithin 1 hr3–8 hr12–24 hr
PO-ERunknownunknown24 hr
SLunknown4 hr24 hr

‡Full effects may not occur for 1–2 wk.

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

sye-kloe-BEN-za-preen

Code ⬆

NDC Code