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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: arrhythmias, DEEP VEIN THROMBOSIS

Derm: rash, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, urticaria

GI: ↑liver enzymes, cholelithiasis, HEPATOTOXICITY, pancreatitis

Metab: ↓HDL-C

MS: RHABDOMYOLYSIS

Neuro: fatigue, headache

Resp: INTERSTITIAL LUNG DISEASE, PULMONARY EMBOLISM

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA)

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Hypertriglyceridemia

Renal Impairment

Primary Hyperlipidemia

Renal Impairment

US Brand Names ⬆ ⬇

Antara, Fenoglide, Lipofen, Tricor, Triglide, Trilipix

Action ⬆ ⬇

  • Fenofibric acid primarily inhibits triglyceride synthesis.
Therapeutic effects:
  • Lowering of triglycerides and LDL-C.

Classifications ⬆ ⬇

Therapeutic Classification: lipid-lowering agents

Pharmacologic Classification: fibric acid derivatives

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed (60%) after oral administration; absorption ↑ by food.

Distribution: Unknown.

Protein Binding: 99%.

Metabolism/Excretion: Rapidly converted to fenofibric acid, which is the active metabolite; fenofibric acid is metabolized by the liver. Fenofibric acid and its metabolites are primarily excreted in urine (60%).

Half-Life: 20 hr.

Canadian Brand Names ⬆ ⬇

Lipidil EZ, Lipidil Supra

Time/Action Profile ⬆ ⬇

( lowering of triglycerides)

ROUTEONSETPEAKDURATION
POunknown2 wkunknown

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

fen-o-FI-brate

Pill Image

fenofibrate_195-8975.jpg

Code ⬆

NDC Code