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Indications ⬇

REMS


Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Interactions ⬆ ⬇

Drug-drug:

Drug-Food:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Minocin, Minolira, Solodyn

Action ⬆ ⬇

  • Inhibit bacterial protein synthesis at the level of the 30S bacterial ribosome.
Therapeutic effects:
  • Bacteriostatic action against susceptible bacteria.

Spectrum:

Classifications ⬆ ⬇

Therapeutic Classification: anti-infectives

Pharmacologic Classification: tetracyclines

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed from the GI tract. IV administration results in complete bioavailability.

Distribution: Widely distributed, some CSF and good bone penetration.

Metabolism/Excretion: 5–20% excreted unchanged by the urine; some metabolism by the liver with enterohepatic circulation and excretion in bile and feces.

Half-Life: 11–26 hr.

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTEONSETPEAKDURATION
POrapid2–3 hr6–12 hr
PO—ERunknown3.5–4 hr24 hr
IVunknownunknownunknown

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

min-oh-SYE-kleen

Code ⬆

NDC Code