section name header

Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: rash, urticaria

GI: CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), diarrhea, nausea

Hemat: bleeding, eosinophilia, hemolytic anemia, leukopenia, thrombocytopenia

Local: pain at IM site, phlebitis at IV site

Neuro: SEIZURES(HIGH DOSES)

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS) , superinfection

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Renal Impairment

US Brand Names ⬆ ⬇

Cefotan,

Action ⬆ ⬇

  • Inhibits bacterial cell wall synthesis.
Therapeutic effects:
  • Bactericidal action against susceptible bacteria.

Spectrum:

  • Similar to that of first-generation cephalosporins but has increased activity against several other gram-negative pathogens including:
    • Haemophilus influenzae(including β-lactamase-producing strains),
    • Escherichia coli,
    • Klebsiella pneumoniae,
    • Morganella morganii,
    • Neisseria gonorrhoeae,
    • Proteus mirabilis,
    • Proteus vulgaris,
    • Providencia rettgeri,
    • Serratia marcescens,
  • Also has activity against Bacteroides fragilis.
  • Not active against methicillin-resistant staphylococci or enterococci.

Classifications ⬆ ⬇

Therapeutic Classification: anti-infectives

Pharmacologic Classification: second generation cephalosporins

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed following IM administration; IV administration results in complete bioavailability.

Distribution: Widely distributed. Penetration into CSF is poor. Crosses the placenta and enters breast milk in low concentrations.

Metabolism/Excretion: Excreted primarily unchanged by the kidneys.

Protein Binding: 88%.

Half-Life: 3–4.6 hr.

Time/Action Profile ⬆ ⬇

ROUTEONSETPEAKDURATION
IMrapid1–3 hr12 hr
IVrapidend of infusion12 hr

Patient/Family Teaching ⬆ ⬇

  • Advise patient to report signs of superinfection (furry overgrowth on the tongue, vaginal itching or discharge, loose or foul-smelling stools) and allergy.
  • Caution patients that concurrent use of alcohol and cefotetan may cause a disulfiram-like reaction (abdominal cramps, nausea, vomiting, headache, hypotension, palpitations, dyspnea, tachycardia, sweating, flushing). Alcohol and alcohol-containing medications should be avoided during and for several days after therapy.
  • Instruct patient to notify health care professional if fever and diarrhea develop, especially if stool contains blood, pus, or mucus. Advise patient not to treat diarrhea without consulting health care professional.
  • Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Pronunciation ⬆ ⬇

sef-oh-TEE-tan

Code ⬆

NDC Code