plecanatide

Contraindicated in:

Known/suspected mechanical GI obstruction;
Pedi: Children <6 yr (↑ risk of dehydration).

Use Cautiously in:

OB: Safety not established in pregnancy; fetal exposure to plecanatide or its active metabolite unlikely;
Lactation: Use while breastfeeding only if potential maternal benefit justifies potential risk to infant;
Pedi: Children 6–18 yr (safety and effectiveness not established).

Adv. Reactions/Side Effects ⬆ ⬇

GI: ↑liver enzymes, abdominal distention, diarrhea, flatulence

Interactions ⬆ ⬇

Drug-drug:

None reported.

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

PO (Adults ): 3 mg once daily.

US Brand Names ⬆ ⬇

Action ⬆ ⬇

Locally ↑ cyclic guanosine monophosphate concentrations, which ↑ intestinal fluid and accelerates transit time.

Therapeutic effects:

Increased frequency of complete spontaneous bowel movements.

Classifications ⬆ ⬇

Therapeutic Classification: laxatives

Pharmacologic Classification: guanylate cyclase-C agonists

Pharmacokinetics ⬆ ⬇

Absorption: Minimally absorbed, action is primarily local.

Distribution: Stays within the GI tract with minimal distribution.

Metabolism/Excretion: Converted to its principal active metabolite within the GI tract. Plecanatide and active metabolite and then degrade in intestinal lumen to smaller peptides and amino acids. Excretion information unknown.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

( improvement in symptoms)

ROUTE		ONSET		PEAK		DURATION
PO		1 wk		2–12 wk		2 wk‡

‡Following discontinuation.

Patient/Family Teaching ⬆ ⬇

Explain the purpose and side effects of plecanatide. Instruct patient to take as directed. If a dose is missed, omit and take next dose at regular time; do not double doses. Advise patient to read Patient Information before starting and with each Rx refill in case of changes.
Instruct patient to notify health care provider of all Rx or OTC medications, vitamins, or herbal products being taken and consult health care provider before taking any new medications.
Rep: Advise women of reproductive potential to notify health care provider if pregnancy is planned or suspected or if breastfeeding.

Pronunciation ⬆ ⬇

Code ⬆

NDC Code

14799- Zhejiang Supor Pharmaceuticals Co., Ltd
- 14799-3004-
  - 14799-3004-1- 50 g in 1 BAG (14799-3004-1)

14799- Zhejiang Supor Pharmaceuticals Co., Ltd
- 14799-3004-
  - 14799-3004-2- 10 g in 1 BAG (14799-3004-2)

14799- Zhejiang Supor Pharmaceuticals Co., Ltd
- 14799-3004-
  - 14799-3004-3- 5 g in 1 BAG (14799-3004-3)

14799- Zhejiang Supor Pharmaceuticals Co., Ltd
- 14799-3004-
  14799-3004-4- 1 g in 1 BOTTLE, PLASTIC (14799-3004-4)

41524- Ambiopharm, Inc.
- 41524-0014-
  41524-0014-1- 1000 g in 1 BOTTLE (41524-0014-1)

52076- Chunghwa Chemical Synthesis & Biotech. Ltd
- 52076-6226-
  52076-6226-1- 5 kg in 1 DRUM (52076-6226-1)

52076- Chunghwa Chemical Synthesis & Biotech. Ltd
- 52076-6226-
  52076-6226-2- 50 kg in 1 DRUM (52076-6226-2)

52076- Chunghwa Chemical Synthesis & Biotech. Ltd
- 52076-6226-
  52076-6226-3- 200 kg in 1 DRUM (52076-6226-3)

59651- Aurobindo Pharma Limited
- 59651-619-
  59651-619-37- 1 kg in 1 BOTTLE, GLASS (59651-619-37)

65015- MYLAN LABORATORIES LIMITED
- 65015-891-
  65015-891-61- 10 kg in 1 DRUM (65015-891-61)

65649- Salix Pharmaceuticals Inc.
- 65649-003- Trulance Immediate release
  65649-003-01- 1 BOTTLE in 1 CARTON (65649-003-01) / 1 TABLET in 1 BOTTLE

65649- Salix Pharmaceuticals Inc.
- 65649-003- Trulance Immediate release
  - 65649-003-03- 1 BOTTLE in 1 CARTON (65649-003-03) / 3 TABLET in 1 BOTTLE

65649- Salix Pharmaceuticals Inc.
- 65649-003- Trulance Immediate release
  - 65649-003-07- 1 BOTTLE in 1 CARTON (65649-003-07) / 7 TABLET in 1 BOTTLE

65649- Salix Pharmaceuticals Inc.
- 65649-003- Trulance Immediate release
  - 65649-003-30- 30 TABLET in 1 BOTTLE (65649-003-30)

69766- MSN Life Sciences Private Limited
- 69766-071-
  - 69766-071-01- 50 kg in 1 DRUM (69766-071-01)

84206- Tianish Laboratories Private Limited
- 84206-0077-
  84206-0077-1- 10 kg in 1 DRUM (84206-0077-1)

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Indications ⬇

Contraind./Precautions ⬆ ⬇