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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Exercise Extreme Caution in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: hypotension, chest pain, edema

Derm: rash

GI: abdominal pain, diarrhea, nausea, vomiting

GU: erectile dysfunction, impaired renal function

F and E: hyperkalemia

MS: muscle cramps

Neuro: dizziness, fatigue, headache, insomnia, weakness

Resp: cough, dyspnea

Misc: ANGIOEDEMA

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

Hypertension

Heart Failure

US Brand Names ⬆ ⬇

Monopril

Action ⬆ ⬇

  • Angiotensin-converting enzyme (ACE) inhibitors block the conversion of angiotensin I to the vasoconstrictor angiotensin II. ACE inhibitors also prevent the degradation of bradykinin and other vasodilatory prostaglandins. ACE inhibitors also ↑ plasma renin levels and ↓ aldosterone levels. Net result is systemic vasodilation.
Therapeutic effects:
  • Lowering of BP in patients with hypertension.
  • Decreased afterload and symptoms in patients with HF.

Classifications ⬆ ⬇

Therapeutic Classification: antihypertensives

Pharmacologic Classification: ace inhibitors

Pharmacokinetics ⬆ ⬇

Absorption: 36% absorbed following oral administration.

Distribution: Minimally distributed to tissues.

Protein Binding: 99.4%.

Metabolism/Excretion: Converted by the liver and GI mucosa to fosinoprilat, the active metabolite: 50% excreted in urine; 50% in feces.

Half-Life: 12 hr.

Time/Action Profile ⬆ ⬇

(effect on BP—single dose‡)
ROUTEONSETPEAKDURATION
POWithin 1 hr2–6 hr24 hr

‡Full effects may not be noted for several wk.

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

foe-SIN-oh-pril

Code ⬆

NDC Code