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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: bradycardia, hypotension

Derm: flushing, burning sensation, contact dermatitis, erythema, pallor

EENT: nasopharyngitis

Neuro: dizziness, headache

Misc: HYPERSENSITIVITY REACTIONS(INCLUDING ANGIOEDEMA, ANAPHYLAXIS, AND URTICARIA)

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)
  • Topical gel: 0.33%

Route/Dosage ⬆ ⬇

  • (Adults ): Apply pea-sized amount to each of five areas on the face (forehead, chin, nose and each cheek) once daily.

US Brand Names ⬆ ⬇

Mirvaso

Action ⬆ ⬇

  • Acts as a selective alpha-2 adrenergic agonist, causing direct vasoconstriction.
Therapeutic effects:
  • Decreased erythema.

Classifications ⬆ ⬇

Therapeutic Classification: cosmetic agents

Pharmacologic Classification: alpha adrenergic agonists

Pharmacokinetics ⬆ ⬇

Absorption: Some absorption follows topical use.

Distribution: Unknown.

Metabolism/Excretion: Extensively metabolized by the liver; drug and metabolites are excreted in urine.

Half-Life: Unknown.

Canadian Brand Names ⬆ ⬇

Onreltea

Time/Action Profile ⬆ ⬇

(↓ erythema)
ROUTEONSETPEAKDURATION
topwithin 3 hr3–6 hr≥12 hr

Patient/Family Teaching ⬆ ⬇

  • Explain purpose and side effects of medication to patient. Advise patient to read Patient Information before starting therapy. Advise patient in correct application of brimonidine.
  • Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
  • Advise patient that erythema or flushing may occur; usually diminishes 30 min to several hours after application; resolves after discontinuation.
  • Advise patient that hypersensitivity reactions following gel application can occur. Discontinue therapy and seek immediate medical attention if necessary.
  • Advise patient to avoid excessive sun exposure, heat, spicy foods, and alcohol, which can worsen rosacea.
  • Rep: Advise women of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Pronunciation ⬆ ⬇

bri-MOE-ni-deen

Code ⬆

NDC Code