Risk of irritation ↑ by other topical skin-care products (aftershave, cover-up, make-up, perfumes, colognes).
Availability⬆⬇
(Generic available)
Cream: 0.1%
Gel: 0.1%; 0.3% OTC
Lotion: 0.1%
Solution: 0.1%
In combination with:
benzoyl peroxide (Epiduo, Epiduo Forte); benzoyl peroxide and clindamycin (Cabtreo) (see Combination Drugs).
Route/Dosage⬆⬇
(Adults and Children ≥12 yr): Apply once daily at bedtime.
US Brand Names⬆⬇
Differin
Action⬆⬇
Binds to retinoic acid nuclear receptors resulting in decreased microcomedone formation.
Therapeutic effects:
Reduction in inflammatory and noninflammatory acne lesions.
Classifications⬆⬇
Therapeutic Classification: antiacne agents
Pharmacologic Classification: retinoids
Pharmacokinetics⬆⬇
Absorption: Minimal systemic absorption occurs with limited surface-area application.
Distribution: Unknown.
Metabolism/Excretion: Excreted via the biliary route.
Half-Life: Unknown.
Time/Action Profile⬆⬇
(improved skin appearance)
ROUTE
ONSET
PEAK
DURATION
Topical
8–12 wk
unknown
unknown
Patient/Family Teaching⬆⬇
Explain purpose and side effects of medication to patient. Advise patient to read Patient Information before starting therapy. Advise patient on correct technique for application of cream.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
Advise patient that a temporary worsening of acne may occur at beginning of therapy.
Advise patient to use sunscreen and protective clothing to prevent photosensitivity reactions. Health care professional should be consulted about sunscreen, as some sunscreens may worsen acne.
Rep: Advise women of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
Pronunciation⬆⬇
a-DAP-a-leen
Code⬆
NDC Code
0168- E. Fougera & Co. a division of Fougera Pharmaceuticals Inc.
0168-0424- Adapalene
0168-0424-46- 1 TUBE in 1 CARTON (0168-0424-46) / 45 g in 1 TUBE
0299- Galderma Laboratories, L.P.
0299-4910- Differin
0299-4910-00- 1 TUBE in 1 BLISTER PACK (0299-4910-00) / 2 g in 1 TUBE
0299- Galderma Laboratories, L.P.
0299-4910- Differin
0299-4910-10- 1 BOTTLE, PUMP in 1 CARTON (0299-4910-10) / 15 g in 1 BOTTLE, PUMP
0299- Galderma Laboratories, L.P.
0299-4910- Differin
0299-4910-15- 1 TUBE in 1 CARTON (0299-4910-15) / 15 g in 1 TUBE
0299- Galderma Laboratories, L.P.
0299-4910- Differin
0299-4910-40- 1 BOTTLE, PUMP in 1 CARTON (0299-4910-40) / 45 g in 1 BOTTLE, PUMP
0299- Galderma Laboratories, L.P.
0299-4910- Differin
0299-4910-45- 1 TUBE in 1 CARTON (0299-4910-45) / 45 g in 1 TUBE
