Oral medications taken within 1 hr of start may not be properly absorbed.
Concurrent use of other laxatives may ↑ risk of mucosal ulcerations.
May ↑ risk of digoxin toxicity in the presence of electrolyte abnormalities.
Availability⬆⬇
(Generic available)
Oral solution (for adults)lemon: 17.5 g sodium sulfate/3.13 g potassium sulfate/1.6 g magnesium sulfate/6 oz.
Oral solution (for children 12 yr)lemon: 13.13 g sodium sulfate/2.35 g potassium sulfate/1.2 g magnesium sulfate/4.5 oz
Route/Dosage⬆⬇
PO (Adults ): One 6-oz bottle during evening before colonoscopy, repeated during the morning prior to the colonoscopy (10–12 hr after evening dose). Additional clear liquids are required after each dose.
PO (Children ≥12 yr): One 4.5-oz bottle during evening before colonoscopy, repeated during the morning prior to the colonoscopy (10–12 hr after evening dose). Additional clear liquids are required after each dose.
US Brand Names⬆⬇
Suprep Bowel Prep Kit
Action⬆⬇
Unabsorbed cations and anions in the GI tract cause osmotic laxative effect by causing water retention in the GI tract.
Therapeutic effects:
With concurrent fluid ingestion, produces watery diarrhea and colonic purging in preparation for colonoscopy.
Classifications⬆⬇
Therapeutic Classification: laxatives
Pharmacologic Classification: osmotics
Pharmacokinetics⬆⬇
Absorption: Minimal systemic absorption.
Distribution: Action is primarily local.
Metabolism/Excretion: Not metabolized; primarily eliminated via fecal excretion.
Half-Life: 8.5 hr.
Time/Action Profile⬆⬇
(onset of watery diarrhea)
ROUTE
ONSET
PEAK
DURATION
PO
within hr
unknown
unknown
Patient/Family Teaching⬆⬇
Instruct patient in correct technique for preparing and taking prep kit. Solution must be diluted as directed; ingestion of undiluted solution may increase risk of nausea, vomiting, and dehydration.
Advise patient to hydrate adequately before, during, and after prep. Advise patient to expect watery diarrhea after ingesting prep kit.
Inform patients to avoid taking other oral medications within 1 hr of each dose of prep kit; they may not be absorbed.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
Instruct patient to avoid taking other laxatives while taking prep kit.
Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.