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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

EENT: sneezing, throat irritation, nasal irritation

Resp: cough

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Tyrvaya

Action ⬆ ⬇

  • Acts as an agonist at nicotinic acetylcholine receptor, which activates the trigeminal parasympathetic pathway, leading to enhanced basal tear film production.
Therapeutic effects:
  • Increased tear film production.

Classifications ⬆ ⬇

Therapeutic Classification: none assigned

Pharmacologic Classification: cholinergics

Pharmacokinetics ⬆ ⬇

Absorption: Minor systemic absorption.

Distribution: Minimal tissue distribution.

Metabolism/Excretion: Undergoes minimal metabolism. 92% excreted unchanged in the urine.

Half-Life: 19 hr.

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTEONSETPEAKDURATION
Intranasalunknown2 hrunknown

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

var-EN-i-kleen

Code ⬆

NDC Code