Tuberculosis
- PO IV (Adults ): 600 mg/day or 10 mg/kg/day (up to 600 mg/day) single dose; may also be given twice weekly.
- PO IV (Children and Infants): 10–20 mg/kg/day single dose or divided every 12 hr (not to exceed 600 mg/day); may also be given twice weekly.
Asymptomatic Carriers of Meningococcus
- PO IV (Adults ): 600 mg every 12 hr for 2 days.
- PO IV (Children ≥1 mo): 10 mg/kg every 12 hr for 2 days (max: 600 mg/dose).
- PO (Infants <1 mo): 5 mg/kg every 12 hr for 2 days.
H. influenzae Prophylaxis
- PO (Adults ): 600 mg/day for 4 days.
- PO (Children ): 20 mg/kg/day for 4 days (max: 600 mg/dose).
- PO (Neonates ): 10 mg/kg/day for 4 days.
Synergy for S. aureus Infections
- PO (Adults ): 300–600 mg twice daily.
- PO (Children and Neonates): 5–20 mg/kg/day divided every 12 hr (max: 600 mg/dose).
