Most Infections
- PO (Adults ): 250–500 mg every 8 hr or 500–875 mg every 12 hr (not to exceed 2–3 g/day).
- PO (Children >3 mo): 25–50 mg/kg/day in divided doses every 8 hr or 25–50 mg/kg/day in divided doses every 12 hr; Acute otitis media due to highly resistant strains of S. pneumoniae: 80–90 mg/kg/day in divided doses every 12 hr; Postexposure inhalational anthrax prophylaxis:<40 kg: 45 mg/kg/day in divided doses every 8 hr; >40 kg: 500 mg every 8 hr.
- PO (Infants ≤3 mo and neonates): 20–30 mg/kg/day in divided doses every 12 hr.
Renal Impairment
- PO (Adults ): CCr 10–30 mL/min: 250–500 mg every 12 hr; CCr <10 mL/min: 250–500 mg every 24 hr.
Helicobacter pylori
- PO (Adults ): Triple therapy: 1000 mg amoxicillin twice daily with lansoprazole 30 mg twice daily and clarithromycin 500 mg twice daily for 14 days or 1000 mg amoxicillin twice daily with omeprazole 20 mg twice daily and clarithromycin 500 mg twice daily for 14 days or amoxicillin 1000 mg twice daily with esomeprazole 40 mg daily and clarithromycin 500 mg twice daily for 10 days. Dual therapy: 1000 mg amoxicillin three times daily with lansoprazole 30 mg three times daily for 14 days.
Endocarditis Prophylaxis
- PO (Adults ): 2 g 1 hr prior to procedure.
- PO (Children ): 50 mg/kg 1 hr prior to procedure (not to exceed adult dose).
- PO (Adults and Children ≥40 kg): 3 g as a single dose.
- PO (Children >2 yr and <40 kg): 50 mg/kg with probenecid 25 mg/kg as a single dose.
