Therapeutic Classification: anticoagulants
Pharmacologic Classification: coumarins
Absorption: Well absorbed from the GI tract after oral administration.
Distribution: Minimally distributed to tissues.
Protein Binding: 99%.
Metabolism/Excretion: Primarily metabolized by the liver via the CYP2C9 isoenzyme, with some metabolism via the CYP3A4 isoenzyme; the CYP2C9 isoenzyme exhibits genetic polymorphism (intermediate or poor metabolizers may have significantly ↑ (S)-warfarin concentrations and an ↑ risk of adverse reactions).
Half-Life: 42 hr.
( effects on coagulation tests)
| ROUTE | ONSET | PEAK | DURATION |
|---|
| PO | 36–72 hr | 5–7 days‡ | 2–5 days‡ |
‡At a constant dose
‡After discontinuation
