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Indications ⬇

REMS

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: orthostatic hypotension

EENT: intraoperative floppy iris syndrome, rhinitis

GU: priapism, retrograde/diminished ejaculation

Neuro: dizziness, headache

Interactions ⬆ ⬇

Drug-drug:

Availability ⬆ ⬇

(Generic available)

Route/Dosage ⬆ ⬇

US Brand Names ⬆ ⬇

Flomax

Action ⬆ ⬇

  • Decreases contractions in smooth muscle of the prostatic capsule by preferentially binding to alpha1-adrenergic receptors.
Therapeutic effects:
  • Decreased symptoms of BPH (urinary urgency, hesitancy, nocturia).

Classifications ⬆ ⬇

Therapeutic Classification: benign prostatic hyperplasia bph agents

Pharmacologic Classification: alpha adrenergic blockers

Pharmacokinetics ⬆ ⬇

Absorption: >90% absorbed after oral administration.

Distribution: Widely distributed to tissues.

Protein Binding: 94–99%.

Metabolism/Excretion: Primarily metabolized by the liver via the CYP3A4 and CYP2D6 isoenzymes; the CYP2D6 enzyme system exhibits genetic polymorphism (∼7% of population may be poor metabolizers and may have significantly ↑ tamsulosin concentrations and an ↑ risk of adverse effects).<10% excreted unchanged in urine.

Half-Life: 14 hr.

Canadian Brand Names ⬆ ⬇

Flomax CR

Time/Action Profile ⬆ ⬇

(↑ in urine flow)
ROUTEONSETPEAKDURATION
POunknown2 wkunknown

Patient/Family Teaching ⬆ ⬇

Pronunciation ⬆ ⬇

tam-SOO-loe-sin

Pill Image

tamsulosin_195-8336.jpg

Code ⬆

NDC Code