- Following the abrupt discontinuation of therapy with beta blockers, severe exacerbation of angina and the occurrence of myocardial infarction and ventricular arrhythmias have been reported in angina patients . If the angina worsens or acute coronary insufficiency develops, it is recommended that drug administration be promptly reinstituted, as least temporarily. Do not discontinue therapy abruptly even in patients treated only for hypertension
- Concomitant use of calcium channel blockers may cause bradycardia and heart block and increased left ventricular end diastolic pressure. Patients with pre-existing conduction abnormalities or left ventricular dysfunction are particularly susceptible
- It should not be used in patients with bronchospastic disease unless patients do not respond to or cannot tolerate other therapy. Administer beta-2 stimulating agent concomitantly and use lowest possible dose; start smaller doses tid to avoid higher plasma levels
- Do not withdraw therapy prior to surgery in the majority of patients. Take care when using anesthetic agents which may depress the myocardium
- Therapy should be used with caution in diabetic patients if a betablocking agent is required; as it may mask tachycardia occurring with hypoglycemia
- Do not administer in patients with untreated pheochromocytoma
- It may mask signs of hyperthyroidism; avoid abrupt withdrawal due to the risk of precipitating a thyroid storm. Patients suspected of developing thyrotoxicosis should be managed carefully to avoid abrupt withdrawal of therapy, which might precipitate a thyroid storm
Cautions: Use cautiously in
- Renal impairment
- Peripheral vascular disease
- Bronchospastic disease
- Major surgery
- Diabetes mellitus
- Thyroid disorder
- WPW syndrome
- Myasthenia gravis
- History of severe anaphylactic reactions
- Elderly patients
Pregnancy Category:B
Breastfeeding: Safe. Therapy would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 1 April 2011). According to manufacturer data nursing should not be undertaken by mothers receiving the drug since pindolol is secreted in human milk.
Pricing data from www.DrugStore.com in U.S.A.
- Pindolol 5 MG TABS [Bottle] (MYLAN)
60 mg = $55.99
120 mg = $105.98 - Pindolol 10 MG TABS [Bottle] (MYLAN)
60 mg = $70.99
180 mg = $194.97
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
