Adult Dosing
Drug induced methemoglobinemia
- 65-130 mg PO tid after meals with a full glass (240 mL) of water
- Maintenance: 100–300 mg daily in chronic methemoglobinemia
Chronic urolithiasis
Pediatric Dosing
Drug induced methemoglobinemia
- 65-130 mg PO tid after meals with a full glass (240 mL) of water
- Maintenance: 100–300 mg daily in chronic methemoglobinemia
Chronic urolithiasis
- Therapy may cause serious CNS reactions when methylene given to patients taking certain serotonergic psychiatric medications
- Complete blood counts including reticulocyte counts recommended following methylene blue therapy to assure that hemolysis has not occurred
- Monitor methemoglobin concentrations 1 to 2 hours following administration of methylene blue to assess the effectiveness of therapy
- Closely monitor patients for greenish blue to blue discoloration of urine and feces; diarrhea nausea and vomiting; painful urination or increased urinary frequency
Cautions: Use cautiously in
- G6PD deficiency
- Pediatrics
- Elderly patients
Pregnancy Category:C
Breastfeeding: Safety unknown. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
