Adult Dosing
Prevention of chemotherapy induced nausea and vomiting
- Day 1: 125 mg PO 1 hr prior to chemotherapy treatment
- Day 2 - 3: 80 mg PO qam
- Note: Administer in combination with a corticosteroid and 5-HT3 antagonist
Prevention of postoperative nausea and vomiting
- 40 mg PO within 3 hours prior to induction of anesthesia
- Note: EMEND (fosaprepitant dimeglumine) IV (115) may be substituted for oral EMEND (125 mg), 30 minutes prior to chemotherapy, on Day 1 only of the CINV regimen
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
[Outline]
- Dose-dependent inhibitor of CYP3A4; use with caution in patients receiving concomitant medications metabolized through CYP3A4
- Coadministration with warfarin may result in significant decrease in International Normalized Ratio (INR) of prothrombin time
- Monitor patient for antiemetic efficacy
- Not recommended for chronic continuous administration
- Avoid coadministration of other antiemetics
- May reduce efficacy of hormonal contraceptives; advise patients to use alternative or back-up methods of contraception during treatment
Cautions: Use cautiously in
- Severe hepatic impairment
- Concurrent use with any agents metabolized by CYP3A4
Pregnancy Category:B
Breastfeeding: Safety Unknown; caution advised
Pricing data from www.DrugStore.com in U.S.A.
- Emend 80 MG CAPS [Disp Pack] (MERCK SHARP & DOHME)
2 mg = $217.03
6 mg = $624.97 - Emend 80 & 125 MG CAPS [Disp Pack] (MERCK SHARP & DOHME)
3 mg = $383.99
9 mg = $1111.92 - Emend 125 MG CAPS [Box] (MERCK SHARP & DOHME)
6 mg = $944
18 mg = $2707.09
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.