section name header

Use and Dosing

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Opioid Dependence (treatment in accordance with the treatment standards cited in the Code of Federal Regulation, Title 42, Section 8.12)

Detoxification

Short term detoxification

Maintenence therapy

Medically supervised withdrawal (after a period of maintenance treatment)

Pain, moderate to severe

Opioid nontolerant patients

Opioid tolerant patients

Total daily baseline
ORAL morphine dose
Estimated daily ORAL
methadone requirement
(% of total daily morphine dose)
<100 mg20-30%
100-300 mg10-20%
300-600 mg8-12 %
600-1000 mg5-10 %
> 1000 mg< 5%
Notes:

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[Outline]

Indications

Contraindications

Black Box Warnings

Dosing Adjustment

Renal Dose Adjustment

Hepatic Dose Adjustment

Warnings/Precautions

See Supplemental Patient Information

Cautions: Use cautiously in

Supplemental Patient Information

Interactions

Dolophine, Methadose, Westadone interacts with :

significance_3.gifAgenerase
significance_3.gifAkne-mycin
significance_3.gifAmprenavir
significance_3.gifAnafranil
significance_3.gifAprepitant
significance_3.gifAtazanavir
significance_2.gifAzilect
significance_3.gifBarbiturates
significance_3.gifBiaxin
significance_3.gifBiaxin XL
significance_3.gifBoceprevir
significance_3.gifBosentan
significance_3.gifBrintellix
significance_3.gifBrisdelle
significance_3.gifCalan
significance_3.gifCalan SR
significance_3.gifCarbamazepine
significance_3.gifCarbatrol
significance_3.gifCardizem
significance_3.gifCardizem CD
significance_3.gifCardizem LA
significance_3.gifCartia XT
significance_3.gifCelexa
significance_3.gifCeritinib
significance_3.gifCetraxal
significance_3.gifCiloxan
significance_3.gifCimetidine
significance_3.gifCipro
significance_3.gifCipro IV
significance_3.gifCipro XR
significance_3.gifCiprofloxacin
significance_3.gifCitalopram
significance_3.gifClarithromycin
significance_3.gifClomipramine
significance_3.gifClotrimazole
significance_3.gifCobicistat
significance_3.gifConivaptan
significance_3.gifCovera-HS
significance_3.gifCrixivan
significance_3.gifCyclosporine
significance_3.gifCymbalta
significance_3.gifDabrafenib
significance_3.gifDarunavir
significance_3.gifDelavirdine
significance_3.gifDesvenlafaxine
significance_3.gifDiflucan
significance_3.gifDilacor XR
significance_3.gifDilantin
significance_3.gifDilantin Infatabs
significance_3.gifDilantin-125
significance_3.gifDilt-CD
significance_3.gifDiltiazem
significance_3.gifDiltzac
significance_3.gifDronedarone
significance_3.gifDuloxetine
significance_3.gifE-Mycin
significance_3.gifE.E.S.
significance_3.gifEfavirenz
significance_3.gifEffexor
significance_3.gifEffexor XR
significance_2.gifEldepryl
significance_3.gifEmend
significance_2.gifEmsam
significance_3.gifEpitol
significance_3.gifEquetro
significance_3.gifEry-Tab
significance_3.gifEryc
significance_3.gifErygel
significance_3.gifEryped
significance_3.gifErythra-Derm
significance_3.gifErythro-statin
significance_3.gifErythrocin
significance_3.gifErythromycin
significance_3.gifEscitalopram
significance_3.gifEtravirine
significance_3.gifExtina
significance_3.gifFetzima
significance_3.gifFluconazole
significance_3.gifFluoxetine
significance_3.gifFluvoxamine
significance_3.gifFungicure Intensive Pump Spray
significance_3.gifFungicure Manicure & Pedicure
significance_3.gifFungicure Pump Spray
significance_1.gifFurazolidone
significance_1.gifFuroxone
significance_3.gifGengraf
significance_3.gifGleevec
significance_3.gifGrapefruit
significance_3.gifGyne-Lotrimin
significance_3.gifGyne-Lotrimin 3
significance_3.gifGyne-Lotrimin 3 combination pack
significance_3.gifGyne-Lotrimin combination pack
significance_3.gifImatinib
significance_3.gifImipramine
significance_3.gifIncivek
significance_3.gifIndinavir
significance_3.gifIntelence
significance_3.gifInvirase
significance_1.gifIsocarboxazid
significance_3.gifIsoptin
significance_3.gifIsoptin SR
significance_3.gifItraconazole
significance_3.gifJuxtapid
significance_3.gifKetek
significance_3.gifKetoconazole
significance_3.gifKhedezla
significance_3.gifKorlym
significance_3.gifLapatinib
significance_3.gifLevomilnacipran
significance_3.gifLexapro
significance_2.gifLinezolid
significance_3.gifLomitapide
significance_3.gifLotrimin AF
significance_3.gifLumacaftor
significance_3.gifLuvox
significance_3.gifLuvox CR
significance_1.gifMarplan
significance_1.gifMethblue
significance_1.gifMethylene Blue
significance_3.gifMifepristone
significance_3.gifMilnacipran
significance_3.gifMultaq
significance_3.gifMycelex
significance_3.gifMycelex 7
significance_3.gifMycelex 7 combination pack
significance_3.gifMysoline
significance_1.gifNardil
significance_3.gifNefazodone
significance_3.gifNelfinavir
significance_3.gifNeoral
significance_3.gifNevirapine
significance_3.gifNizoral
significance_3.gifNizoral A-D Shampoo
significance_3.gifNizoral Shampoo
significance_3.gifNorvir
significance_3.gifNoxafil
significance_3.gifOnmel
significance_3.gifOrkambi
significance_3.gifOxcarbazepine
significance_3.gifOxtellar XR
significance_1.gifParnate
significance_3.gifParoxetine
significance_3.gifPaxil
significance_3.gifPaxil CR
significance_3.gifPCE
significance_3.gifPediamycin
significance_3.gifPexeva
significance_1.gifPhenelzine
significance_3.gifPhenytek
significance_3.gifPhenytoin
significance_3.gifPosaconazole
significance_3.gifPrezista
significance_3.gifPriftin
significance_3.gifPrimidone
significance_3.gifPristiq
significance_3.gifProquin XR
significance_3.gifProzac
significance_3.gifProzac Weekly
significance_3.gifQuinupristin
significance_2.gifRasagiline
significance_3.gifRescriptor
significance_3.gifRestasis
significance_3.gifReyataz
significance_3.gifRifadin
significance_3.gifRifampin
significance_3.gifRifapentine
significance_3.gifRimactane
significance_3.gifRitonavir
significance_2.gifSafinamide
significance_3.gifSandimmune
significance_3.gifSaquinavir
significance_3.gifSarafem
significance_3.gifSavella
significance_2.gifSelegiline
significance_3.gifSelfemra
significance_3.gifSertraline
significance_3.gifSporanox
significance_3.gifSt. John's wort
significance_3.gifStribild
significance_3.gifSustiva
significance_3.gifSynercid
significance_3.gifTafinlar
significance_3.gifTagamet
significance_3.gifTagamet HB
significance_3.gifTAO
significance_3.gifTaztia XT
significance_3.gifTegretol
significance_3.gifTegretol XR
significance_3.gifTelaprevir
significance_3.gifTelithromycin
significance_3.gifTeril
significance_3.gifTiazac
significance_3.gifTofranil
significance_3.gifTofranil-PM
significance_3.gifTracleer
significance_1.gifTranylcypromine
significance_3.gifTrileptal
significance_3.gifTrivagizole 3
significance_3.gifTroleandomycin
significance_3.gifTykerb
significance_1.gifUrolene Blue
significance_3.gifVaprisol
significance_3.gifVenlafaxine
significance_3.gifVeralan
significance_3.gifVerapamil
significance_3.gifVerelan PM
significance_3.gifVfend
significance_3.gifVictrelis
significance_3.gifViibryd
significance_3.gifVilazodone
significance_3.gifViracept
significance_3.gifViramune
significance_3.gifViramune XR
significance_3.gifVoriconazole
significance_3.gifVortioxetine
significance_2.gifXadago
significance_3.gifXolegel
significance_2.gifZelapar
significance_3.gifZoloft
significance_3.gifZykadia
significance_2.gifZyvox

Pregnancy/Breast Feeding

Pregnancy Category:C

Breastfeeding: Methadone is excreted in breast milk. When used as maternal maintenance therapy, breastfeeding may decrease neonatal withdrawal symptoms in infants who were exposed in utero. However, it is excreted in only small amounts, a breastfed infant may require treatment for withdrawal. Initiation of methadone postpartum, or increasing the maternal dosage to > 100 mg/day therapeutically or by abuse, subjects the infant to a greater risk of sedation and respiratory depression. Monitor infant for signs of increased sedation, breathing difficulties, or limpness. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT). This drug is considered compatible with breastfeeding based upon data from from AAP Policy Guidelines (available at http://aappolicy.aappublications.org/cgi/content/full/pediatrics;108/3/776 last accessed 22 July 2010)

Adverse Reactions

Clinical Pharmacology

Brands and Availability

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US Trade Name(s)

US Availability

methadone (generic)

Dolophine

Methadose

Westadone

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Canadian Trade Name(s)

Canadian Availability

Metadol, Metadol-D

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UK Trade Name(s)

UK Availability

methadone (generic)

Methadose

Metharose

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Australian Trade Name(s)

Australian Availability

methadone (generic)

Biodone forte

Physeptone


[Outline]

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Classification

Analgesics

Opioid Analgesics
Opioid Agonists

Pricing

Pricing data from www.DrugStore.com in U.S.A.

Warning.gifWarning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

Pill