Adult Dosing

Short-term treatment of obesity

Tenuate

• 25 mg PO tid before meals and in midevening

Tenuate Dospan

• 75 mg PO qd in midmorning

Pediatric Dosing

• Safety and effectiveness in pediatric patients have not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• Short-term adjunct in a regimen of weight reduction based on caloric restriction in a treatment of exogenous obesity

• Hypersensitivity to any of the ingredients of the product
• Pulmonary hypertension
• Advanced arteriosclerosis
• Hyperthyroidism
• Idiosyncrasy to the sympathomimetic amines
• Glaucoma
• Severe hypertension
• Agitated states
• History of drug abuse
• Anorectic agents
• Monoamine oxidase inhibitor
• Valvular heart diseases
• Heart murmur

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Avoid using in combination with other anorectic agents, including prescribed drugs, OTC preparations, and herbal products
• Therapy may increased risk of pulmonary hypertension, in such cases immediately discontinued the therapy and monitor the patient
• Valvular heart disease has been often reported when therapy is given with other concomitant medication. Valvulopathy may occur when medication is taken as monotherapy
• Consider baseline cardiac evaluation to detect preexisting valvular heart diseases or pulmonary hypertension prior to initiation of therapy
• To avoid unwarranted exposure and risks, treatment should be continued only if the patient has satisfactory weight loss within the first 4 weeks of treatment, and if tolerance develops, the recommended dose should not be exceeded in an attempt to increase the effect; rather, the drug should be discontinued
• Therapy may impair the ability of the patient to engage in hazardous activities such as operating machinery or driving a motor vehicle; thus patient should be cautioned accordingly
• Prolonged use of therapy may induce dependence with withdrawal syndrome. Hallucinations may occur in rare cases, and several cases of toxic psychosis have been reported following the excessive use of the drug. If psychosis occurs, discontinue the treatment

Cautions: Use cautiously in

• Elderly patients
• Cardiovascular disorder
• Psychiatric disorder
• Seizure disorder

Tenuate, Tenuate Dospan interacts with :

	Azilect
	Eldepryl
	Emsam
	Furazolidone
	Furoxone
	Isocarboxazid
	Linezolid
	Marplan
	Methblue
	Methylene Blue
	Nardil
	Parnate
	Phenelzine
	Rasagiline
	Safinamide
	Selegiline
	Tranylcypromine
	Urolene Blue
	Xadago
	Zelapar
	Zyvox

Pregnancy Category:B

Breastfeeding: Since drug and its metabolites have been shown to be excreted in human milk. Manufacturer advises caution.

• CNS: Dependency abuse, seizures, dizziness, insomnia, headache, overstimulation, nervousness, drowsiness, malaise, cerebrovascular accident
• PSYCHIATRY: Psychosis, hallucinations, restlessness, anxiety, jitteriness, euphoria, dysphoria
• GI: Constipation, dry mouth, nausea, vomiting, diarrhea, abdominal discomfort, unpleasant taste
• GU: Impotence, libido changes, gynecomastia, menstrual upset, dysuria, polyuria
• HEMA: Agranulocytosis, leukopenia, bone marrow depression
• DERM: Rash, urticaria, ecchymosis, erythema, hair loss, increased sweating
• EENT: Blurred vision, mydriasis
• RESP: Dyspnea
• MUSC: Dyskinesia, muscle pain

• Anorexiant; raises levels of leptin which signal satiety center in brain, causing appetite suppression
• Metabolism: N-dealkylation and reduction; CYP450; unknown
• Excretion: Urine (75-100%)
• Half-life: 4-6 hrs

US Trade Name(s)

• Tenuate
• Tenuate Dospan

US Availability

diethylpropion (generic)

• TABS: 25 mg
• ETABS: 75 mg

Tenuate

• TABS: 25 mg

Tenuate Dospan

• ETABS: 75 mg

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Endocrine/Metabolic

Anorexiants

Pricing data from www.DrugStore.com in U.S.A.

• Diethylpropion HCl CR 75 MG TB24 [Bottle] (WATSON LABS)
  10 mg = $19.99
  20 mg = $29.98

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

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