section name header

Use and Dosing ⬇

Adult Dosing

Unresectable or metastatic melanoma with BRAF V600E mutation

Pediatric Dosing

Indications ⬆ ⬇

Note: dabrafenib is not indicated for the treatment of patients with wild-type BRAF melanoma

Contraindications ⬆ ⬇

Black Box Warnings ⬆ ⬇

Dosing Adjustment ⬆ ⬇

Renal Dose Adjustment

Hepatic Dose Adjustment

Warnings/Precautions ⬆ ⬇

Interactions ⬆ ⬇

Tafinlar interacts with :

significance_3.gifA-methapred
significance_3.gifAbilify
significance_3.gifAbilify discmelt
significance_3.gifAbilify Maintena
significance_2.gifAbiraterone
significance_3.gifAbstral
significance_2.gifAcenocoumarol
significance_3.gifAciphex
significance_3.gifActiq
significance_3.gifAdalat CC
significance_2.gifAdcetris
significance_3.gifAdcirca
significance_2.gifAddyi
significance_2.gifAdriamycin
significance_3.gifAfeditab CR
significance_2.gifAfinitor
significance_2.gifAgenerase
significance_3.gifAkne-mycin
significance_3.gifAlfenta
significance_3.gifAlfentanil
significance_3.gifAltropev
significance_2.gifAmaryl
significance_3.gifAmiodarone
significance_3.gifAmitriptyline
significance_3.gifAmlodipine
significance_3.gifAmoxapine
significance_2.gifAmprenavir
significance_3.gifAnafranil
significance_2.gifAnastrozole
significance_3.gifApixaban
significance_2.gifAprepitant
significance_2.gifArimidex
significance_3.gifAripiprazole
significance_3.gifAristocort
significance_2.gifAromasin
significance_3.gifAsendin
significance_2.gifAstagraf XL
significance_3.gifAstramorph PF
significance_2.gifAtazanavir
significance_3.gifAtorvastatin
significance_3.gifAvanafil
significance_2.gifAvandia
significance_3.gifAventyl
significance_3.gifAventyl Hydrochloride
significance_3.gifAvinza
significance_3.gifAxid
significance_3.gifAxid AR
significance_3.gifAzmacort
significance_3.gifBarbiturates
significance_3.gifBaypress
significance_2.gifBedaquiline
significance_3.gifBepridil
significance_2.gifBexarotene
significance_3.gifBiaxin
significance_3.gifBiaxin XL
significance_3.gifBoceprevir
significance_2.gifBortezomib
significance_3.gifBosentan
significance_2.gifBrentuximab
significance_3.gifBrexpiprazole
significance_3.gifBudesonide
significance_2.gifCabazitaxel
significance_3.gifCalan
significance_3.gifCalan SR
significance_3.gifCarbamazepine
significance_3.gifCarbatrol
significance_3.gifCardene
significance_3.gifCardene SR
significance_3.gifCardizem
significance_3.gifCardizem CD
significance_3.gifCardizem LA
significance_3.gifCartia XT
significance_3.gifCetraxal
significance_2.gifChlorpropamide
significance_3.gifCialis
significance_3.gifCiloxan
significance_3.gifCimetidine
significance_3.gifCipro
significance_3.gifCipro IV
significance_3.gifCipro XR
significance_3.gifCiprofloxacin
significance_3.gifClarithromycin
significance_3.gifClomipramine
significance_3.gifClozapine
significance_3.gifClozaril
significance_3.gifCobicistat
significance_3.gifCodeine
significance_3.gifConivaptan
significance_2.gifContraceptives, Oral
significance_3.gifCordarone
significance_2.gifCorlanor
significance_3.gifCortisone
significance_3.gifCortone
significance_2.gifCoumadin
significance_3.gifCovera-HS
significance_2.gifCrixivan
significance_3.gifCutivate
significance_2.gifCyclophosphamide
significance_2.gifCyclosporine
significance_2.gifCytoxan
significance_2.gifDaclatasvir
significance_2.gifDaklinza
significance_2.gifDarunavir
significance_3.gifDecadron
significance_2.gifDelavirdine
significance_3.gifDepo-Medrol
significance_3.gifDepodur
significance_3.gifDesipramine
significance_3.gifDexamethasone
significance_3.gifDexilant
significance_3.gifDexlansoprazole
significance_2.gifDiaBeta
significance_2.gifDiabinese
significance_3.gifDiflucan
significance_3.gifDilacor XR
significance_3.gifDilantin
significance_3.gifDilantin Infatabs
significance_3.gifDilantin-125
significance_3.gifDilt-CD
significance_3.gifDiltiazem
significance_3.gifDiltzac
significance_3.gifDisopyramide
significance_2.gifDocetaxel
significance_3.gifDolophine
significance_3.gifDoxepin
significance_2.gifDoxorubicin
significance_3.gifDronedarone
significance_3.gifDuragesic
significance_3.gifDuramorph
significance_3.gifDynacirc
significance_3.gifDynacirc CR
significance_3.gifE-Mycin
significance_3.gifE.E.S.
significance_2.gifEdurant
significance_3.gifEfavirenz
significance_3.gifElavil
significance_3.gifEliquis
significance_3.gifElixophyllin
significance_2.gifEmend
significance_3.gifEntocort
significance_3.gifEntocort EC
significance_2.gifEnzalutamide
significance_3.gifEpitol
significance_3.gifEquetro
significance_3.gifEry-Tab
significance_3.gifEryc
significance_3.gifErygel
significance_3.gifEryped
significance_3.gifErythra-Derm
significance_3.gifErythro-statin
significance_3.gifErythrocin
significance_3.gifErythromycin
significance_3.gifEsomeprazole
significance_2.gifEtoposide
significance_2.gifEtravirine
significance_2.gifEverolimus
significance_2.gifExemestane
significance_3.gifExtina
significance_3.gifFamotidine
significance_3.gifFanapt
significance_2.gifFareston
significance_2.gifFarydak
significance_3.gifFazaclo ODT
significance_3.gifFelodipine
significance_2.gifFemara
significance_3.gifFentanyl
significance_3.gifFentora
significance_2.gifFlibanserin
significance_3.gifFlo-Pred
significance_3.gifFlonase
significance_3.gifFlovent
significance_3.gifFlovent Diskus
significance_3.gifFlovent HFA
significance_3.gifFluconazole
significance_3.gifFluticasone
significance_3.gifFluvoxamine
significance_3.gifFluxid
significance_2.gifGengraf
significance_3.gifGeodon
significance_2.gifGlimepiride
significance_2.gifGlipizide
significance_2.gifGlucotrol
significance_2.gifGlucotrol XL
significance_2.gifGlucovance
significance_2.gifGlyburide
significance_2.gifGlynase
significance_3.gifGrapefruit
significance_2.gifHecoria
significance_2.gifIfex
significance_2.gifIfosfamide
significance_3.gifIloperidone
significance_3.gifImipramine
significance_2.gifIncivek
significance_2.gifIndinavir
significance_3.gifInfumorph
significance_3.gifINH
significance_2.gifIntelence
significance_2.gifInvirase
significance_3.gifIsoniazid
significance_3.gifIsoptin
significance_3.gifIsoptin SR
significance_3.gifIsradipine
significance_3.gifItraconazole
significance_2.gifIvabradine
significance_2.gifIxabepilone
significance_2.gifIxazomib
significance_2.gifIxempra
significance_2.gifJantoven
significance_2.gifJevtana
significance_3.gifJuxtapid
significance_3.gifKadian
significance_2.gifKaletra
significance_3.gifKapidex
significance_3.gifKenalog
significance_3.gifKenalog-10
significance_3.gifKenalog-40
significance_3.gifKetek
significance_3.gifKetoconazole
significance_3.gifKorlym
significance_3.gifLamictal
significance_3.gifLamictal CD
significance_3.gifLamictal ODT
significance_3.gifLamictal XR
significance_3.gifLamotrigine
significance_3.gifLansoprazole
significance_3.gifLatuda
significance_3.gifLazanda
significance_2.gifLetrozole
significance_3.gifLevitra
significance_3.gifLipitor
significance_3.gifLomitapide
significance_2.gifLopinavir
significance_3.gifLovastatin
significance_3.gifLumacaftor
significance_3.gifLurasidone
significance_3.gifLuvox
significance_3.gifLuvox CR
significance_2.gifMaraviroc
significance_3.gifMaxidex
significance_3.gifMedrol
significance_3.gifMethadone
significance_3.gifMethadose
significance_3.gifMethylprednisolone
significance_3.gifMevacor
significance_3.gifMifepristone
significance_3.gifMillipred
significance_3.gifMorphine
significance_3.gifMS Contin
significance_3.gifMultaq
significance_3.gifMycobutin
significance_3.gifMysoline
significance_3.gifNasacort allergy 24 Hour
significance_3.gifNasacort AQ
significance_2.gifNateglinide
significance_3.gifNefazodone
significance_2.gifNelfinavir
significance_2.gifNeoral
significance_3.gifNevirapine
significance_3.gifNexium
significance_3.gifNexium IV
significance_3.gifNexterone
significance_3.gifNicardipine
significance_3.gifNifediac CC
significance_3.gifNifedical XL
significance_3.gifNifedipine
significance_3.gifNimodipine
significance_3.gifNimotop
significance_2.gifNinlaro
significance_3.gifNisoldipine
significance_3.gifNitrendipine
significance_3.gifNizatidine
significance_3.gifNizoral
significance_3.gifNizoral A-D Shampoo
significance_3.gifNizoral Shampoo
significance_3.gifNorpace
significance_3.gifNorpace CR
significance_3.gifNorpramin
significance_3.gifNortriptyline
significance_3.gifNorvasc
significance_3.gifNorvir
significance_3.gifNoxafil
significance_3.gifNymalize
significance_2.gifOdomzo
significance_3.gifOlanzapine
significance_3.gifOmeprazole
significance_3.gifOmnipred
significance_3.gifOnmel
significance_3.gifOnsolis
significance_3.gifOramorph SR
significance_3.gifOrapred
significance_3.gifOrapred ODT
significance_3.gifOrasone
significance_2.gifOrinase
significance_3.gifOrkambi
significance_3.gifOxcarbazepine
significance_3.gifOxecta
significance_3.gifOxtellar XR
significance_3.gifOxycodone
significance_3.gifOxycontin
significance_3.gifOxyFast
significance_3.gifOzudrex
significance_3.gifPacerone
significance_2.gifPaclitaxel
significance_3.gifPamelor
significance_2.gifPanobinostat
significance_3.gifPantoprazole
significance_3.gifPCE
significance_3.gifPediamycin
significance_3.gifPepcid
significance_3.gifPepcid AC
significance_3.gifPepcid RPD
significance_3.gifPercocet
significance_2.gifPhenprocoumon
significance_3.gifPhenytek
significance_3.gifPhenytoin
significance_3.gifPlendil
significance_3.gifPosaconazole
significance_3.gifPred forte
significance_3.gifPred mild
significance_3.gifPrednisolone
significance_3.gifPrednisone
significance_3.gifPrelone
significance_3.gifPrevacid
significance_3.gifPrevacid 24 HR OTC
significance_2.gifPrezista
significance_3.gifPriftin
significance_3.gifPrilosec
significance_3.gifPrilosec OTC
significance_3.gifPrimidone
significance_3.gifProcardia
significance_3.gifProcardia XL
significance_2.gifPrograf
significance_3.gifProquin XR
significance_3.gifProtonix
significance_3.gifProtonix IV
significance_2.gifProtopic
significance_3.gifProtriptyline
significance_3.gifPulmicort flexhaler
significance_3.gifPulmicort respules
significance_3.gifPulmicort turbuhaler
significance_3.gifQuetiapine
significance_3.gifQuinidex
significance_3.gifQuinidine
significance_3.gifQuinupristin
significance_3.gifRabeprazole
significance_2.gifRanexa
significance_3.gifRanitidine
significance_2.gifRanolazine
significance_2.gifRapamune
significance_3.gifRayos
significance_2.gifRescriptor
significance_2.gifRestasis
significance_3.gifRetrovir
significance_3.gifRevatio
significance_3.gifRexulti
significance_2.gifReyataz
significance_3.gifRhinocort
significance_3.gifRifabutin
significance_3.gifRifadin
significance_3.gifRifampin
significance_3.gifRifapentine
significance_2.gifRilpivirine
significance_3.gifRimactane
significance_3.gifRisperdal
significance_3.gifRisperdal Consta
significance_3.gifRisperdal M-Tab
significance_3.gifRisperidone
significance_3.gifRitonavir
significance_3.gifRivaroxaban
significance_2.gifRosiglitazone
significance_3.gifRoxicodone
significance_2.gifSandimmune
significance_2.gifSaquinavir
significance_2.gifSelzentry
significance_3.gifSeroquel
significance_3.gifSeroquel XR
significance_3.gifSildenafil
significance_3.gifSilenor
significance_3.gifSimvastatin
significance_3.gifSinequan
significance_2.gifSirolimus
significance_2.gifSirturo
significance_3.gifSolu-Medrol
significance_2.gifSonidegib
significance_3.gifSporanox
significance_2.gifSt. John's wort
significance_2.gifStarlix
significance_3.gifStaxyn
significance_3.gifStendra
significance_3.gifSterapred
significance_3.gifSterapred DS
significance_3.gifStribild
significance_3.gifSublimaze
significance_3.gifSubsys
significance_3.gifSufenta
significance_3.gifSufentanil
significance_3.gifSular
significance_3.gifSurmontil
significance_3.gifSustiva
significance_3.gifSynercid
significance_2.gifTacrolimus
significance_3.gifTadalafil
significance_3.gifTagamet
significance_3.gifTagamet HB
significance_3.gifTAO
significance_2.gifTargretin
significance_2.gifTaxol
significance_2.gifTaxotere
significance_3.gifTaztia XT
significance_3.gifTegretol
significance_3.gifTegretol XR
significance_2.gifTelaprevir
significance_3.gifTelithromycin
significance_2.gifTeniposide
significance_3.gifTeril
significance_3.gifTheo-24
significance_3.gifTheochron
significance_3.gifTheolair
significance_3.gifTheophylline
significance_3.gifTiazac
significance_3.gifTofranil
significance_3.gifTofranil-PM
significance_2.gifTolbutamide
significance_2.gifToremifene
significance_2.gifTrabectedin
significance_3.gifTracleer
significance_3.gifTriacet
significance_3.gifTriamcinolone
significance_3.gifTriderm
significance_3.gifTriesence
significance_3.gifTrileptal
significance_3.gifTrimipramine
significance_3.gifTroleandomycin
significance_3.gifUceris
significance_3.gifVaprisol
significance_3.gifVardenafil
significance_3.gifVascor
significance_2.gifVelcade
significance_2.gifVenclexta
significance_2.gifVenetoclax
significance_2.gifVepesid
significance_3.gifVeralan
significance_3.gifVeramyst
significance_3.gifVerapamil
significance_3.gifVerelan PM
significance_3.gifVeripred 20
significance_3.gifVersacloz
significance_3.gifVfend
significance_3.gifViagra
significance_3.gifVictrelis
significance_2.gifViracept
significance_3.gifViramune
significance_3.gifViramune XR
significance_3.gifVivactil
significance_3.gifVoriconazole
significance_2.gifVumon
significance_2.gifWarfarin
significance_3.gifWestadone
significance_3.gifXarelto
significance_3.gifXolegel
significance_2.gifXtandi
significance_2.gifYondelis
significance_3.gifZantac
significance_3.gifZantac 150
significance_3.gifZantac 25
significance_3.gifZantac 300
significance_3.gifZantac 75
significance_3.gifZidovudine
significance_3.gifZiprasidone
significance_3.gifZocor
significance_3.gifZonalon
significance_3.gifZyprexa
significance_3.gifZyprexa Relprevv
significance_3.gifZyprexa Zydis
significance_2.gifZytiga

Pregnancy/Breast Feeding ⬆ ⬇

Pregnancy Category:D

Breastfeeding: Safety unknown. As many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother

Adverse Reactions ⬆ ⬇

Clinical Pharmacology ⬆ ⬇

Brands and Availability ⬆ ⬇

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US Trade Name(s)

US Availability

Tafinlar

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Canadian Trade Name(s)

Canadian Availability

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UK Trade Name(s)

UK Availability

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Australian Trade Name(s)

Australian Availability

Classification ⬆

Hematology/Oncology

Antineoplastics
Tyrosine Kinase Inhibitors