Adult Dosing
Prophylaxis of angina pectoris
- TABS:
- Usual dose: 20 mg PO every morning then 20 mg 7 hours later
- Max: 40 mg/day
- Extended Release TABS:
- Start 30-60 mg PO daily; then increase dose to 120 mg to 240 mg PO daily after several days if needed
Note:
- Do not chew/crush extended release tabs
- Doses of 240 mg/day are rarely required
Pediatric Dosing
- Safety and effectiveness in pediatrics has not been established
[Outline]
- Concomitant administration of sildenafil amplifies the vasodilatory effect of isosorbide mononitrate resulting in to severe hypotension. Treat this condition as nitrate overdose with elevation of the extremities and with central volume expansion
- The benefits of immediate-release or extended release oral isosorbide mononitrate in acute myocardial infarction or congestive heart failure have not been established. If used in this condition closely monitor clinical and hemodynamic conditions to avoid the hazards of hypotension and tachycardia, as it is difficult to terminate the effect of isosorbide mononitrate rapidly
- Even a small dose of isosorbide mononitrate can cause severe hypotension, particularly with upright posture. Hence use cautiously in volume depleted or hypotensive patients
- Isosorbide mononitrate induced hypotension is accompanied by paradoxical bradycardia and increased angina pectoris
- Angina caused by hypertrophic cardiomyopathy is aggravated by nitrate therapy
- Blunt exercise tolerance is observed with sublingual nitroglycerin therapy
- Administration of nitroglycerine for continuous 12 hrs of every 24-hour day, easily provoked anginal attacks, demonstrated hemodynamic rebound and decreased exercise tolerance during the interdosing intervals
- Long-term exposure to nitroglycerin demonstrates physical dependence and causes chest pain, acute myocardial infarction, and even sudden death during temporary withdrawal
Cautions: Use cautiously in
- Volume depletion
- Hypotension
- Acute MI
- CHF
- Hypertrophic cardiomyopathy
Pregnancy Category:C
Breastfeeding: Safety unknown, manufacturer advises caution.
US Trade Name(s)
- Monoket
- Imdur ER [Discontinued]
US Availability
isosorbide mononitrate (generic)
- TABS: 10, 20 mg
- ETABS: 30, 60, 120 mg
Imdur ER
Monoket
Canadian Trade Name(s)
Canadian Availability
UK Trade Name(s)
- Chemydur 60XL
- Mitrate 60XL
- Elantan 10
- Elantan 20
- Monomil 20
- Carmil 20
- Elantan 40
- Monomil 40
- Carmil 40
- Elantan LA25
- Isotard 25XL
- Elantan LA50
- Imdur
- Isotard 25XL
- Isotard 40XL
- Isotard 50XL
- Isotard 60XL
- Modisal 60XL
- Slomon XL60
- Monomax XL60
- Monomil XL
- Carmil XL
- Tardisc XL
- Trangina XL
- Isib 60 XL
- Cibral 60 XL
- Xismox 60 XL
- Monomax SR 40
- Monomax SR 60
- Trangina XL
UK Availability
isosorbide mononitrate (generic)
Chemydur 60XL, Mitrate 60XL
Elantan 10
Elantan 20, Monomil 20, Carmil 20
Elantan 40, Monomil 40, Carmil 40
Elantan LA25
Elantan LA50
Imdur
Isotard 25XL
Isotard 40XL
Isotard 50XL
Isotard 60XL, Modisal 60XL, Slomon XL60, Monomax XL60, Monomil XL, Carmil XL, Tardisc XL, Trangina XL, Isib 60 XL, Cibral 60 XL, Xismox 60 XL
Monomax SR 40
Monomax SR 60
Australian Trade Name(s)
- Duride
- Imdur Durules
- Monodur Durules
- Imtrate SR
- Isomonit
Australian Availability
isosorbide mononitrate (generic)
Duride
Imdur Durules, Monodur Durules
Imtrate SR, Isomonit
[Outline]
Pricing data from www.DrugStore.com in U.S.A.
- Monoket 10 MG TABS [Bottle] (SCHWARZ PHARMA)
60 mg = $101.99
180 mg = $289.96 - Imdur 60 MG TB24 [Bottle] (SCHERING)
30 mg = $95.3
90 mg = $271.08 - Isosorbide Mononitrate 10 MG TABS [Bottle] (KREMERS URBAN)
60 mg = $25.99
180 mg = $55.97 - Monoket 20 MG TABS [Bottle] (SCHWARZ PHARMA)
60 mg = $171.99
180 mg = $485.97 - Isosorbide Mononitrate 20 MG TABS [Bottle] (KREMERS URBAN)
60 mg = $19.99
180 mg = $48.99 - Imdur 30 MG TB24 [Bottle] (SCHERING)
30 mg = $89.99
90 mg = $257.91
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
