Adult Dosing
Pediatric Dosing
Severe lower respiratory tract infection due to RSV
- Reconstitute 6 g with 75 mL of Water for injections; then dilute to a total volume of 300 mL of Water for injections
- Dose regimen: 20 mg/mL with continuous aerosol administration for 12-18 hrs/day for 3-7 days, average aerosol concentration for 12 hrs would be 190 mcg/L of air
[Outline]
- Only severe RSV lower respiratory tract infection should be treated with ribavirin.
- The vast majority of infants and children with RSV infection have disease that is mild, self-limited, and does not require hospitalization or antiviral treatment. Many children with mild lower respiratory tract involvement will require shorter hospitalization than would be required for a full course of 3 to 7 days and should not be treated with the drug.
- Sudden deterioration of respiratory function may occur in patient [US Black Box Warning]
- In infants requiring assisted ventilation, it should only be used if the patients are constantly monitored
- Precipitation of the drug in respiratory equipment & consequent accumulation of fluid in the tubing can cause difficulties for patients requiring assisted ventilation
- Ribavirin aerosol is more effective when instituted within the first 3 days of the treatment of bronchiolitis
- It should be used only with small particle aerosol generator
- Institute appropriate standard supportive respiratory and fluid management along with therapy with ribavirin
- Minimize exposure to pregnant women
- Monitor respiratory and electrolyte status
Cautions: Use cautiously in
Virazole interacts with :
