Adult Dosing

Vitamin A deficiency

• 100,000 U IM Daily x 3 days, followed by 50,000 U IM Daily x 2 weeks
• Follow up therapy: 10,000-20,000 U IM Daily x 2 months

Pediatric Dosing

Vitamin A deficiency

>8 yrs

• 100,000 U IM Daily x 3 days, followed by 50,000 U IM Daily x 2 weeks
• Follow up therapy: 10,000-20,000 U IM Dailyt x 2 months

1-8 yrs

• 17,500-35,000 U IM Daily x 10 days
• Follow up therapy: 5,000-10,000 U IM Daily x 2 months

Infants

• 7,500 to 15,000 U IM Daily x 10 days
• Follow up therapy: 5,000-10,000 U IM Daily x 2 months

[Outline]

• Adult Dosing
• Pediatric Dosing

• Treatment of vitamin A deficiency

• Hypersentivity to any of the ingredients of the product
• Pregnancy
• Hypervitaminosis A

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Use of polysorbates in low birthweight infants has been associated with E-Ferol syndrome characterized by thrombocytopenia, renal dysfunction, hepatomegaly, cholestasis, ascites, hypotension and metabolic acidosis
• Closely supervise patients receiving prolonged daily dose administration over 25,000 Units vitamin A
• Blood level assays are not a direct measure of hepatic storage. Adequate Liver storage is required prior to discontinuing therapy
• Single vitamin A deficiency is rare as compared to multiple vitamin deficiency

Cautions: Use cautiously in

• Low birthweight infants
• Chronic therapy >25,000 units/day

Pregnancy Category:X

Breastfeeding: The US Recommended Daily Allowance (RDA) of vitamin A for nursing mothers is 5000 Units.

• NEURO: Irritability, headache, bulging fontanels, increased ICP
• GI: Abdominal discomfort, anorexia, and vomiting
• DERM: Fissures of the lips,drying and cracking of the skin, alopecia, scaling, massive desquamation, increased pigmentation
• EENT: Exophthalmos, papilledema
• REPRODUCTIVE: Hypomenorrhea
• ENDO: Slow growth
• LABTEST: Leukopenia, vitamin A plasma level >1200 U/100 mL
• HEPA: Hepatotoxicity, hepatosplenomegaly, jaundice
• MUSC: Hard tender cortical thickening over the radius and tibia, migratory arthralgia, premature closure of the epiphysis
• HYPERSENSITIVITY: Anaphylactic shock, anaphylactoid type reaction
• MISC: Fatigue, malaise, lethargy

• Vitamin; the retinal component of vitamin A combines with the rod pigment, opsin, in the retina to form rhodopsin, required for visual dark adaptation. Vitamin A prevents growth retardation and maintains integrity of epithelial cells
• Readily absorbed from the GI tract
• Metabolized in the liver by conjugation with glucuronic acid
• Excretion: Unknown
• Half-life: 1.9 hrs

US Trade Name(s)

• Aquasol A

US Availability

Aquasol A

• INJ: 50,000 USP Units (2 mL vial)

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Nutrition/Electrolytes

Vitamins