Adult Dosing

Hypertension

• Start 5 mg PO qd; 2.5 mg PO qd in elderly pts.
• Titrate: q2 weeks as needed
• Usual: 2.5-10 mg PO qd
• MAX: 10 mg/day

• Monitor BP closely during any dosage adjustment for elderly pts.
• Do not crush or chew ETABS

Pediatric Dosing

• Safety and effectiveness in pediatric population have not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• Hypertension (alone or concomitantly with other antihypertensive agents)

• Hypersensitivity to any of the ingredient of the product

• N/A

Renal Dose Adjustment

• Renal impairment: No dose adjustments
• Hemodialysis: No supplement

Hepatic Dose Adjustment

• Hepatic impairment: Start 2.5 mg qd. MAX: 10 mg

• Doses exceeding 10 mg/day increase the rate of peripheral edema and vasodilatory adverse effects
• Geriatric patients should receive a starting dose of 2.5 mg/day
• Avoid grapefruit juice
• Mild gingival hyperplasia has been reported; good dental hygiene decreases its severity
• Monitor BP during dosage adjustments, especially in the elderly and those with hepatic function impairment

Cautions: Use cautiously in

• CHF
• Elderly pts
• Hepatic impairment
• Concomitant use of CYP3A4 inhibitors (ketoconazole, itraconazole, erythromycin)

Plendil interacts with :

	Agenerase
	Akne-mycin
	Amiodarone
	Amprenavir
	Aprepitant
	Atazanavir
	Barbiturates
	Biaxin
	Biaxin XL
	Boceprevir
	Bosentan
	Carbamazepine
	Carbatrol
	Ceritinib
	Cetraxal
	Ciloxan
	Cipro
	Cipro IV
	Cipro XR
	Ciprofloxacin
	Clarithromycin
	Cloxacillin
	Cloxapen
	Cobicistat
	Conivaptan
	Cordarone
	Crixivan
	Cyclosporine
	Dabrafenib
	Darunavir
	Delavirdine
	Dicloxacillin
	Diflucan
	Dilantin
	Dilantin Infatabs
	Dilantin-125
	Dronedarone
	Dynapen
	E-Mycin
	E.E.S.
	Emend
	Epitol
	Equetro
	Ery-Tab
	Eryc
	Erygel
	Eryped
	Erythra-Derm
	Erythro-statin
	Erythrocin
	Erythromycin
	Extina
	Fluconazole
	Fluvoxamine
	Gengraf
	Grapefruit
	Grifulvin V
	Gris-Peg
	Grisactin
	Griseofulvin
	Incivek
	Indinavir
	Invirase
	Itraconazole
	Juxtapid
	Ketek
	Ketoconazole
	Korlym
	Lomitapide
	Luvox
	Luvox CR
	Mifepristone
	Multaq
	Mycobutin
	Mysoline
	Nafcillin
	Nallpen
	Nefazodone
	Nelfinavir
	Neoral
	Nexterone
	Nizoral
	Nizoral A-D Shampoo
	Nizoral Shampoo
	Norvir
	Noxafil
	Onmel
	Oxcarbazepine
	Oxtellar XR
	Pacerone
	PCE
	Pediamycin
	Phenytek
	Phenytoin
	Posaconazole
	Prezista
	Priftin
	Primidone
	Proquin XR
	Quinupristin
	Rescriptor
	Restasis
	Reyataz
	Rifabutin
	Rifadin
	Rifampin
	Rifapentine
	Rimactane
	Ritonavir
	Sandimmune
	Saquinavir
	Sporanox
	St. John's Wort
	Stribild
	Synercid
	Tafinlar
	TAO
	Tegretol
	Tegretol XR
	Telaprevir
	Telithromycin
	Teril
	Tracleer
	Trileptal
	Troleandomycin
	Unipen
	Vaprisol
	Vfend
	Victrelis
	Viracept
	Voriconazole
	Xolegel
	Zykadia

Pregnancy Category:C

Breastfeeding: No data available on the use of felodipine during breastfeeding, an alternate drug may be preferred. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 22 June 2010)

• CV: Arrhythmias, CHF, peripheral edema, bradycardia, chest pain, hypotension, palpitations, syncope, tachycardia
• GI: Nausea, dyspepsia, constipation, abdominal pain, diarrhea, vomiting, dry mouth, flatulence, acid regurgitation
• CNS: Headache, dizziness, paresthesia
• RESP: Upper respiratory tract infection, cough, rhinorrhea, sneezing
• GU: Impotence, urinary frequency, urinary urgency, dysuria, polyuria
• DERM: Rash, flushing, contusion, erythema, urticaria, angioedema
• EENT: Visual disturbances
• HEMA: Anemia

• Blocks calcium ion influx into vascular smooth muscle and myocardium
• Extensively metabolized by liver
• Excreted in urine (70% as metabolites) and feces (10%)
• Half-life: 11-16 hrs

US Trade Name(s)

• Plendil

US Availability

felodipine (generic)

• ETABS: 2.5, 5, 10 mg

Plendil

• ETABS: 2.5, 5, 10 mg

Canadian Trade Name(s)

• Plendil
• Renedil

Canadian Availability

felodipine (generic)

• ETABS: 5, 10 mg

Plendil

• ETABS: 2.5, 5, 10 mg

Renedil

• ETABS: 2.5, 5, 10 mg

UK Trade Name(s)

• Cardioplen XL
• Felotens XL
• Parmid XL
• Plendil
• Vascalpha

UK Availability

felodipine (generic)

• TABS: 2.5, 5, 10 mg

Cardioplen XL

• ETABS: 2.5, 5, 10 mg

Felotens XL

• ETABS: 2.5, 5, 10 mg

Parmid XL

• ETABS: 5, 10 mg

Plendil

• TABS: 2.5, 5, 10 mg

Vascalpha

• ETABS: 5, 10 mg

Australian Trade Name(s)

• Felodil XR
• Felodur ER
• Plendil ER

Australian Availability

Felodil XR

• ETABS: 5, 10 mg

Felodur ER

• ETABS: 2.5, 5, 10 mg

Plendil ER

• ETABS: 2.5, 5, 10 mg

[Outline]

Cardiovascular

Antihypertensive Agents

Calcium Channel Blockers

Pricing data from www.DrugStore.com in U.S.A.

• Felodipine 5 MG TB24 [Bottle] (MYLAN)
  30 mg = $42.99
  90 mg = $119.98
• Plendil 10 MG TB24 [Bottle] (ASTRAZENECA LP)
  30 mg = $89.99
  90 mg = $259.95
• Plendil 2.5 MG TB24 [Bottle] (ASTRAZENECA LP)
  30 mg = $51.99
  90 mg = $137.97
• Felodipine 10 MG TB24 [Bottle] (MYLAN)
  100 mg = $194.98
  200 mg = $388.98
• Felodipine 2.5 MG TB24 [Bottle] (MYLAN)
  30 mg = $43.99
  60 mg = $87.98

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

• 24 HR Plendil 10 MG Extended Release Tablet (AstraZeneca LP)
• 24 HR Plendil 2.5 MG Extended Release Tablet (AstraZeneca LP)
• 24 HR Plendil 5 MG Extended Release Tablet (AstraZeneca LP)
• Felodipine 10 MG 24 HR Extended Release Tablet (Mutual Pharmaceutical Company, Inc.)
• Felodipine 10 MG 24 HR Extended Release Tablet (Mylan Pharmaceuticals Inc.)
• Felodipine 10 MG 24 HR Extended Release Tablet (Ranbaxy Pharmaceuticals Inc)
• Felodipine 2.5 MG 24 HR Extended Release Tablet (Mutual Pharmaceutical Company, Inc.)
• Felodipine 2.5 MG 24 HR Extended Release Tablet (Mylan Pharmaceuticals Inc.)
• Felodipine 2.5 MG 24 HR Extended Release Tablet (Ranbaxy Pharmaceuticals Inc)
• Felodipine 5 MG 24 HR Extended Release Tablet (Mutual Pharmaceutical Company, Inc.)
• Felodipine 5 MG 24 HR Extended Release Tablet (Mylan Pharmaceuticals Inc.)
• Felodipine 5 MG 24 HR Extended Release Tablet (Ranbaxy Pharmaceuticals Inc)