Adult Dosing
Acute migraine attacks with or without aura
- 5-10 mg repeat the dose after a minimum 2 hrs
- Max: 30 mg/24 hrs (3 dose/24 hrs)
- For ODT: Take the tablet without water and just place it on the tongue
- In patients receiving propranolol, use 5 mg dose. Max of 15 mg/24 hours
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
[Outline]
Renal Dose Adjustment
- Renal impairment: Dose adjustments not defined, use with caution
Hepatic Dose Adjustment
- Moderate-severe impairment: Dose adjustments not defined, use with caution
Concomitant use with propranolol
- 5 mg per dose. 15 mg max per day
- Serious adverse cardiac events, including acute MI, arrhythmias, and death, have been reported within a few hours following administration
- Rizatriptan should not be given when risk factors for CAD are present (e.g. hypertension, hypercholesterolemia, diabetes, strong family history of CAD, female with surgical or physiological menopause)
- Coronary vasospasm has occur in patient without any cardiac history or Coronary artery disease. Patient with sign and symptoms of angina should evaluate the dose with presence of CAD or predisposition to Prinzmetal’s variant angina before receiving additional medicine, monitor ECG if symptoms recur
- Sensations of tightness, pain, pressure, and heaviness in the precordium, throat, neck, and jaw have been reported. Patients with such signs or symptoms should be evaluated for the presence of CAD or predisposition to Prinzmetal’s variant angina before receiving additional dose of medication and monitor ECG
- Cerebral hemorrhage, subarachnoid hemorrhage, stroke, and other cerebrovascular events have been reported and some events resulted to be fatal. patient with acute migraine are risk of certain cerebrovascular events (e.g., stroke, hemorrhage, transient ischemic attack)
- Peripheral vascular ischemia and colonic ischemia with abdominal pain and bloody diarrhea have been reported
- Potentially life-threatening serotonin syndrome may occur with co-administration of serotonin re-uptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs)
- Increase in blood pressure have been reported very rarely, contraindicated in patient with uncontrolled hypertension
- Exclude underlying cardiovascular disease, supervise first dose, and consider monitoring ECG in patients with likelihood of unrecognized coronary disease (eg, postmenopausal women, men over age 40, hypertension, hypercholesterolemia, obesity, diabetes, smokers, strong family history)
- Orally disintegrating tablets contain phenylalanine
Cautions: Use cautiously in
- Hypertension
- Renal impairment
- Hepatic impairment
- Diabetes Mellitus
- Concomitant use with SSRI's serotonin syndrome possible
- Elderly patients
Maxalt, Maxalt-MLT interacts with :
Pregnancy Category:C
Breastfeeding: An alternate drug may be preferred, especially while nursing a newborn or preterm infant. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 23 March 2011). Manufacturer advises caution.
Pricing data from www.DrugStore.com in U.S.A.
- Maxalt 10 MG TABS [Box] (MERCK SHARP & DOHME)
18 mg = $531.96
54 mg = $1549.89 - Maxalt-MLT 5 MG TBDP [Box] (MERCK SHARP & DOHME)
3 mg = $315.72
9 mg = $924.36 - Maxalt 5 MG TABS [Box] (MERCK SHARP & DOHME)
12 mg = $353.69
24 mg = $688.95 - Maxalt-MLT 10 MG TBDP [Box] (MERCK SHARP & DOHME)
3 mg = $96.99
6 mg = $184.97
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
