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Use and Dosing

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Major depressive disorder

Bupropion hydrochloride extended-release, Wellbutrin XL

Seasonal affective disorder

Bupropion hydrochloride extended-release, Wellbutrin XL

Major depressive disorder, Seasonal affective disorder

Switching patients from Wellbutrin (bupropion hydrochloride tablets) or from Wellbutrin SR (bupropion hydrochloride extended-release tablets (SR)

Major depressive disorder

Bupropion hydrochloride sustained-release

Major depressive disorder

Aplenzin

Major depressive disorder

Switching Patients from Wellbutrin, Wellbutrin SR or Wellbutrin XL

Major depressive disorder

Wellbutrin

Major depressive disorder

Wellbutrin SR

Notes:

Major depressive disorder

Forfivo XL

Note:

Smoking cessation

Zyban

Notes:

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[Outline]

Indications

Bupropion hydrochloride extended release and bupropion hydrochloride sustained release tablets, Aplenzin, Wellbutrin, Wellbutrin SR, Forfivo XL, Wellbutrin XL

Aplenzin, Wellbutrin XL

Zyban

Contraindications

Black Box Warnings

Dosing Adjustment

Renal Dose Adjustment

Hepatic Dose Adjustment

Mild/Moderate cirrhosis

Severe cirrhosis

Warnings/Precautions

See Supplemental Patient Information

Cautions: Use cautiously in:

Supplemental Patient Information

Interactions

Aplenzin, Forfivo XL, Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban interacts with :

significance_3.gifAbilify
significance_3.gifAbilify discmelt
significance_3.gifAbilify Maintena
significance_3.gifAmitriptyline
significance_3.gifAmoxapine
significance_3.gifAnafranil
significance_3.gifAripiprazole
significance_3.gifAsendin
significance_3.gifAventyl
significance_3.gifAventyl Hydrochloride
significance_3.gifBetimol
significance_3.gifBlocadren
significance_3.gifBrexpiprazole
significance_3.gifBystolic
significance_3.gifCarvedilol
significance_2.gifCerdelga
significance_3.gifClomipramine
significance_3.gifClozapine
significance_3.gifClozaril
significance_3.gifCodeine
significance_3.gifCoreg
significance_3.gifCoreg CR
significance_3.gifDesipramine
significance_3.gifDihydrocodeine
significance_3.gifDoxepin
significance_3.gifElavil
significance_2.gifEliglustat
significance_3.gifFanapt
significance_3.gifFazaclo ODT
significance_2.gifFlecainide
significance_1.gifFurazolidone
significance_1.gifFuroxone
significance_3.gifHemangeol
significance_3.gifHydrocodone
significance_3.gifIloperidone
significance_3.gifImipramine
significance_3.gifInderal
significance_3.gifInderal LA
significance_3.gifInnopran XL
significance_3.gifInvega
significance_3.gifInvega Sustenna
significance_1.gifIsocarboxazid
significance_3.gifIstalol
significance_3.gifLopressor
significance_3.gifLortab
significance_1.gifMarplan
significance_2.gifMellaril
significance_1.gifMethblue
significance_1.gifMethylene Blue
significance_3.gifMetoprolol
significance_2.gifMexiletine
significance_2.gifMexitil
significance_1.gifNardil
significance_3.gifNebivolol
significance_3.gifNicoderm
significance_3.gifNicorette
significance_3.gifNicotrol
significance_2.gifNolvadex
significance_3.gifNorpramin
significance_3.gifNortriptyline
significance_3.gifOlanzapine
significance_3.gifOxecta
significance_3.gifOxycodone
significance_3.gifOxycontin
significance_3.gifOxyFast
significance_3.gifPaliperidone
significance_3.gifPamelor
significance_1.gifParnate
significance_3.gifPercocet
significance_3.gifPercodan
significance_1.gifPhenelzine
significance_2.gifPropafenone
significance_3.gifPropranolol
significance_3.gifProtriptyline
significance_3.gifRexulti
significance_3.gifRisperdal
significance_3.gifRisperdal Consta
significance_3.gifRisperdal M-Tab
significance_3.gifRisperidone
significance_3.gifRoxicodone
significance_2.gifRythmol
significance_2.gifRythmol SR
significance_3.gifSilenor
significance_3.gifSinequan
significance_2.gifSoltamox
significance_3.gifSurmontil
significance_3.gifSynalgos-DC
significance_2.gifTambocor
significance_2.gifTamoxifen
significance_2.gifThioridazine
significance_3.gifTimolol
significance_3.gifTimoptic
significance_3.gifTimoptic in ocudose
significance_3.gifTimoptic-XE
significance_3.gifTofranil
significance_3.gifTofranil-PM
significance_3.gifToprol-XL
significance_1.gifTranylcypromine
significance_3.gifTrimipramine
significance_1.gifUrolene Blue
significance_3.gifVersacloz
significance_3.gifVicodin
significance_3.gifVivactil
significance_3.gifZohydro ER
significance_3.gifZonalon
significance_3.gifZyprexa
significance_3.gifZyprexa Relprevv
significance_3.gifZyprexa Zydis

Pregnancy/Breast Feeding

Pregnancy Category:C

Breastfeeding: Likely unsafe; if bupropion is used during lactation, monitor infants for adverse events including development of seizures, serum levels to rule out toxicity should be monitored. Other drugs may be preferred, especially if breastfeeding a newborn or a preterm infant. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 01 August 2013). Manufacturer advises to make a decision whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Adverse Reactions

Clinical Pharmacology

Brands and Availability

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US Trade Name(s)

US Availability

bupropion hydrochloride (generic)

Aplenzin (bupropion hydrobromide)

Wellbutrin (bupropion hydrochloride)

Wellbutrin SR (bupropion hydrochloride)

Wellbutrin XL (bupropion hydrochloride)

Zyban (bupropion hydrochloride)

Forfivo XL (bupropion hydrochloride)

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Canadian Trade Name(s)

Canadian Availability

bupropion hydrochloride (generic)

Ava-bupropion SR

Bupropion SR

Novo-bupropion SR

PMS-bupropion SR

Ratio-bupropion SR

Sandoz bupropion SR

Wellbutrin SR

Wellbutrin XL

Zyban

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UK Trade Name(s)

UK Availability

Zyban (bupropion hydrochloride)

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Australian Trade Name(s)

Australian Availability

bupropion hydrochloride (generic)

Clorprax, Prexaton, Zyban SR (bupropion hydrochloride)


[Outline]

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Classification

Neurologic

Antidepressants
Antidepressants; Miscellaneous

Psychiatric

Antidepressants
Antidepressants; Miscellaneous

Psychiatric

Smoking Cessation Agents

Pulmonary

Smoking Cessation Agents

Pricing

Pricing data from www.DrugStore.com in U.S.A.

Warning.gifWarning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

Pill