Adult Dosing
Mild-moderate pain/fever
- 325-650 mg PO q 4 hrs; Max: 4 g/day
Rheumatoid arthritis, Arthritis and Pleurisy of SLE
- Initial dose: 3 g/day PO in divided doses q4-6 hrs
- May increase PRN, with target plasma salicylate level of 150-300 mcg/mL
Juvenile rheumatoid arthritis
- Initial dose: 90-130 mg/kg/day PO in divided doses q4-6 hrs
- May increase PRN, with target plasma salicylate level of 150-300 mcg/mL
Spondyloarthropathies
- Up to 4 g/day PO in divided doses q4-6 hrs
Osteoarthritis
- Up to 3 g/day PO in divided doses q4-6 hrs
Ischemic stroke and TIA
Suspected acute MI
- Initial dose: 160-325 mg PO as soon as MI suspected
- Maintenance dose: 160-325 mg PO qd x 30 days post infarction
Prevention of recurrent MI, Unstable angina pectoris, Chronic stable angina pectoris
CABG
- 325 mg PO 6 hrs post procedure
- Maintenance dose: 325 mg PO qd
PTCA
- Initial dose: 325 mg PO 2 hrs pre-surgery
- Maintenance dose: 160-325 mg PO qd
Carotid Endarterectomy
- 80 mg qd-650 mg bid PO, start pre-surgery
Note:
- Each dose should be administered with glass full of water, unless patient is fluid restricted
Acute Coronary Syndromes [Non-FDA Approved]
- Loading dose 300–325 mg PO, then 75-100 mg daily
Kawasaki Diseases [Non-FDA Approved]
- 80-100 mg/kg/day PO divided qid, given either until day 14 of illness or until afebrile for 48-72 hours
- Continued at 3–5 mg/kg PO qd for 6–8 wks. May be discontinued if there is no evidence of coronary abnormalities
Atrial Fibrillation [Non-FDA Approved]
Pediatric Dosing
Mild- moderate pain/fever [>12 yrs]
- 325-650 mg PO q 4 hrs; Max: 4 g/day
Fever [Non-FDA Approved]
- 10-15 mg/kg/dose PO/PR q4-6h up to total of 60-80 mg/kg/day
Kawasaki Diseases [Non-FDA Approved]
- 80-100 mg/kg/day PO divided qid, given either until day 14 of illness or until afebrile for 48-72 hours
- Continued at 3–5 mg/kg PO qd for 6–8 wks. May be discontinued if there is no evidence of coronary abnormalities
Note:- Each dose should be administered with glass full of water, unless patient is fluid restricted
[Outline]
Renal Dose Adjustments (Based on CrCl)
- <10 mL/min: Avoid use
- Mild-moderate renal impairment: Caution advised; dose adjustments not defined
Hepatic Dose Adjustments
- Severe hepatic impairment: Avoid use
- Mild-moderate hepatic impairment: Caution advised; dose adjustments not defined
- Aspirin can cause Reye's syndrome when used in children and teenagers who have, or are recovering from chicken pox or flu-like symptoms, if changes in behavior with nausea and vomiting occur, discontinue the drug and provide appropriate therapy as this can be the early sign of Reye’s syndrome
- Severe allergic reactions are associated with use of aspirin. Blisters, facial swelling, hives, rash, shock and skin reddening are the associated symptoms. Discontinue the treatment at the first appearance of skin rash or any other sign of hypersensitivity like anaphylactoid reactions
- Aspirin inhibits platelet function leading to increase in bleeding time. Hence use cautiously in patients with bleeding disorders
- Aspirin causes inflammation, bleeding, ulceration, and perforation of the stomach. Restrict use in patients with a prior history of peptic ulcer disease or gastrointestinal bleeding, taking blood thinning (anticoagulant) or steroid drug. If a serious GI adverse event is suspected, discontinue the therapy and promptly institute an alternative therapy
- Avoid long term therapy with the drug, concomitant use of oral corticosteroids or anticoagulants, smoking, use of alcohol
- Do not administer in pregnant female during third trimester as it causes premature closure of the ductus arteriosus in the fetus
- Advise patients to stop the use of drug and inform their clinician if they experience bloody vomit, bloody or black stools, stomach pain that does not get better, redness or swelling, ringing in the ears, or loss of hearing
Cautions: Use cautiously in
- Renal impairment
- Hepatic impairment
- Peptic ulcer disease
- GI bleed
- Diabetes mellitus
- Gout
- Chronic alcohol abuse
- Coagulation disorder
- CHF
- Geriatrics
- Diuretic use
Bayer Advanced Aspirin Extra Strength, Bayer Aspirin Extra Strength Plus, Bayer Low Dose Aspirin, Ecotrin, Ecotrin Low Strength, St. Joseph interacts with :
Pregnancy Category:D
Breastfeeding: It is best to avoid aspirin during breastfeeding, especially with very young infants. As per some expert opinion, low dose 75-162 mg of aspirin can be used as an antiplatelet drug in nursing mothers, avoid chronic high dose. Avoid breastfeeding for 1 to 2 hours after a dose, if aspirin is to be taken, to minimize antiplatelet effects in the infant. The risk of Reye's syndrome caused by salicylate in breastmilk is unknown. This information is based upon Lactmed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 4 April 2011). Manufacturer advises avoiding aspirin use in nursing mothers as salicylate is excreted in breast milk.
US Trade Name(s)
- Bayer Low Dose Aspirin
- Bayer Aspirin Extra Strength Plus
- Bayer Advanced Aspirin Extra Strength
- Ecotrin
- Ecotrin Low Strength
- St. Joseph
US Availability
aspirin (generic)
- TABS: 650 mg
- OTC TABS: 325 mg
aspirin extra strength (generic)
aspirin low dose (generic)
- TABS: 81 mg
- CHEW TABS: 81 mg
Ecotrin
Ecotrin Low Strength
St. Joseph
- TABS: 81 mg
- CHEW TABS: 81 mg
Bayer Low Dose Aspirin
Bayer Aspirin Extra Strength Plus
Bayer Advanced Aspirin Extra Strength
Canadian Trade Name(s)
- Asadol
- Asaphen
- Asatab
- Aspergum
- Bufferin
- Bufferin Extra strength
- Entrophen
- Lowprin
- Novasen
- Rivasa
Canadian Availability
acetylsalicylic acid (generic)
- TABS: 325 mg
- ETABS: 80, 81, 325, 500, 650 mg
- CHEW TABS: 80, 81 mg
Acetylsalicylic acid Extra strength (generic)
asprin (generic)
- TABS: 81, 325, 500, 650 mg
- CHEW TABS: 81 mg
- GRAN: 500 mg/pack
asprin Extra Strength(generic)
asprin Arthritis Pain Relief(generic)
asprin Arthritis Pain Relief Extra Strength(generic)
asprin with calcium carbonate (generic)
ASA (generic)
- TABS: 80, 81, 325, 650 mg
- CHEW TABS: 80 mg
ASA Daily Low Dose
- TABS: 81 mg
- CHEW TABS: 81 mg
Asadol
Asaphen
- TABS: 80, 81, 162 mg
- CHEW TABS: 80 mg
Asatab
- ETABS: 325, 650 mg
- CHEW TABS: 80 mg
Aspergum
Bufferin
Bufferin Extra strength
Entrophen
- TABS: 81, 325, 500, 650, 975 mg
- CHEW TABS: 81 mg
Equate Daily Low Dose
Lowprin
- TABS: 80 mg
- CHEW TABS: 80 mg
Novasen
Rivasa
- TABS: 80 mg
- CHEW TABS: 80 mg
UK Trade Name(s)
UK Availability
aspirin (generic)
- TABS: 75, 300 mg
- ODT: 75, 300 mg
Disprin
Micropirin
Australian Trade Name(s)
- Aspro Clear Extra Strength
- Aspro Preparations
- Astrix
- Cardiprin
- Cartia
- Disprin
- Solprin
Australian Availability
aspirin (generic)
Aspro Clear Extra Strength
Aspro Preparations
Astrix
Cardiprin
Cartia
Disprin
Solprin
[Outline]
Pricing data from www.DrugStore.com in U.S.A.
- Ecotrin 325 MG TBEC [Bottle] (GLAXO CONSUMER HEALTHCARE L.P.)
125 mg = $16.99
250 mg = $22.98 - Aspirin 325 MG TABS [Bottle] (RUGBY)
100 mg = $11.99
200 mg = $13.98 - Aspirin 325 MG TABS [Bottle] (MAJOR PHARMACEUTICALS)
500 mg = $14.99
1000 mg = $19.97 - Ecotrin Low Strength 81 MG TBEC [Bottle] (GLAXO CONSUMER HEALTHCARE L.P.)
150 mg = $16.99
450 mg = $29.97 - Aspirin 81 MG CHEW [Bottle] (RUGBY)
36 mg = $11.99
72 mg = $13.98
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
