Adult Dosing

Pheochromocytoma

• Initial: 10 mg PO bid
• Increase 10 mg/day qod to 20-40 mg PO bid-tid until symptomatic relief or BP control

Pediatric Dosing

• Safety and effectiveness in pediatric patients have not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• Treatment of pheochromocytoma, to control episodes of hypertension and sweating

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined, caution advised

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Combination of both alpha and beta adrenergic receptor blocking compounds may exaggerate hypotensive response and tachycardia
• Caution should be exercised in patients with marked cerebral or coronary arteriosclerosis or renal damage
• Adrenergic blocking effect of therapy may aggravate symptoms of respiratory infections

Cautions: Use cautiously in

• Renal impairment
• Cerebrovascular disease
• Respiratory infection
• Long-term use

Pregnancy Category:C

Breastfeeding: Safety unknown. Due to the potential for serious adverse reactions in nursing infants, manufacturer recommends discontinuation of nursing or discontinuation of drug, taking into account the importance of the drug to the mother.

• CNS: Drowsiness
• CV: Postural hypotension, tachycardia
• GI: GI irritation
• EENT: Nasal congestion, miosis
• GU: Inhibition of ejaculation
• MISC: Fatigue

• Alpha-receptor blocking agent; irreversibly blocks alpha-adrenergic receptors
• Bioavailability: 20-30%
• Metabolized by liver
• Excreted in urine, bile
• Half-life: Unknown

US Trade Name(s)

• Dibenzyline

US Availability

phenoxybenzamine

• CAPS: 10 mg

Dibenzyline

• CAPS: 10 mg

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• Dibenyline
• Dibenzyline

Australian Availability

Dibenyline, Dibenzyline

• CAPS: 10 mg

[Outline]

Cardiovascular

Cardiovascular Agents; Miscellaneous

Pricing data from www.DrugStore.com in U.S.A.

• Dibenzyline 10 MG CAPS [Bottle] (WELLSPRING PHARMACEUTICAL CORP)
  30 mg = $255.99
  90 mg = $725.97

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

Drug Name: Dibenzyline 10 MG Oral Capsule

Ingredient(s): Phenoxybenzamine

Imprint: WPC;001;10;mg

Color(s): Red

Shape: Capsule

Size (mm): 10.00

Score: 1

Inactive Ingredient(s): d&c red no. 33 / fd&c red no. 3 / fd&c yellow no. 6 / gelatin / lactose / sodium lauryl sulfate / silicon dioxide

Drug Label Author:
WellSpring Pharmaceutical Corporation

DEA Schedule:
Non-Scheduled