Adult Dosing
Hypothyroidism
- Start 1 tablet of thyrolar 1/2 [T3/T4: 12.5 mcg/50 mcg ]
- May start 1 tablet of thyrolar 1/4 [T3/T4: 3.1 mcg/12.5 mcg] in long standing myxedema if cardiovascular impairment is suspected and reduce the dosage if angina occurs
- Increase 1 tablet of thyrolar 1/4 [T3/T4: 3.1 mcg/12.5 mcg] q2-3 weeks until desired effect
- Titrate slowly if elderly, myxedema, or cardiac risk factors present
- Usual maintenance dose: thyrolar 1-thyrolar 2 [T3/T4: 12.5–25 mcg/day/50–100 mcg/day]
- Re-adjust dosage within first 4 wks of therapy after clinical and laboratory evaluations of serum levels of T4, bound and free, and TSH
Thyroid suppression test
- 1.56 mcg/kg/day PO for 7-10 days; dose expressed as levothyroxine
- Determine radioactive iodine uptake pre and post therapy; > 50% suppression indicated normal thyroid pituitary axis
Pediatric Dosing
Congenital hypothyroidism
- 0-6 months: T3/T4 - [3.1-6.25 mcg/ 12.5-25 mcg]/day
- 6-12 months: T3/T4 - [6.25-9.35 mcg/25-37.5 mcg]/day
- 1-5 yrs: T3/T4- [9.35-12.5 mcg/37.5-50 mcg]/day
- 6-12 yrs: T3/T4- [12.5-18.75 mcg/50-75 mcg]/day
- >12 yrs: T3/T4: >[18.75/75] mcg/day
[Outline]
- Thyroid hormones alone or in combination with other drugs, should not be used for the treatment of obesity or for weight loss. In euthyroid patients, doses within range of daily hormonal requirements are ineffective for weight loss; larger doses may cause serious or life threatening toxicity, especially in combination with sympathomimetic amines including those used for their anorectic effects
- Therapy may aggravate the intensity of symptoms in patient with concomitant diabetes mellitus or diabetes insipidus or adrenal cortical insufficiency
- Upward adjustments of their antidiabetic therapeutic regimens may be required in patients with diabetes mellitus when treated with liotrix
- Patient with myxedema coma requires simultaneous administration of glucocorticoids
- Dose adjustments is necessary to maintain therapeutic response
- Closely monitor prothrombin time in thyroid patient on oral anticoagulants; and adjust the dose on the basis of prothrombin time
- Excessive dose, therapy may cause craniosynostosis in infants
Cautions: Use cautiously in
- Cardiovascular disease
- Angina pectoris
- Diabetes mellitus
- Hypertension
- Infants
- Geriatrics
Thyrolar-0.25, Thyrolar-0.5, Thyrolar-1, Thyrolar-2, Thyrolar-3 interacts with :
Pregnancy Category:A
Breastfeeding: Levothyroxine (T4) and liothyronine (T3) are mixture of liotrix, which is a normal component present in human milk. Limited literature on exogenous replacement doses of levothyroxine during breastfeeding indicates no adverse effects in infants. If liotrix is required by the mother, not a reason to discontinue breastfeeding. liotrix dosage requirement may be increased in the postpartum period compared to pre pregnancy requirements patients with Hashimoto's thyroiditis This information based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 14 June 2011). Manufacturer advises caution.
Pricing data from www.DrugStore.com in U.S.A.
- Thyrolar-2 120 (25-100) MG (MCG) TABS [Bottle] (FOREST)
30 mg (mcg) = $32.99
90 mg (mcg) = $82.98 - Thyrolar-3 180 (37.5-150) MG (MCG) TABS [Bottle] (FOREST)
30 mg (mcg) = $39.99
90 mg (mcg) = $100.98 - Thyrolar-1 60 (12.5-50) MG (MCG) TABS [Bottle] (FOREST)
30 mg (mcg) = $29.99
90 mg (mcg) = $67.97
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
