section name header

Pronunciation

foss-foe-MYE-sin

Classifications

Therapeutic Classification: anti-infectives

Indications

REMS


Action

  • Inactivates an enzyme crucial for bacterial cell wall synthesis.
  • Decreases adherence of bacteria to uroepithelial cells.
Therapeutic effects:
  • Bactericidal action against susceptible bacteria.

Spectrum:

Pharmacokinetics

Absorption: Rapidly absorbed and converted to fosfomycin, its active component, resulting in 37% bioavailability.

Distribution: Distributes to kidneys and bladder wall; crosses the placenta.

Metabolism/Excretion: Excreted unchanged in urine (38%) and feces (18%).

Half-Life: 5.7 hr.

Time/Action Profile

(bactericidal urine levels)
ROUTEONSETPEAKDURATION
POrapid2–4 hrunknown



Symptoms may take 24–48 hr to subside.



Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Interactions

Drug-drug:

Route/Dosage

Availability

(Generic available)

Assessment

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Monurol