section name header

Pronunciation

SER-tra-leen

Classifications

Therapeutic Classification: antidepressants

Pharmacologic Classification: selective serotonin reuptake inhibitors ssris

Indications

BEERS REMS

Unlabeled Uses:

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: Appears to be well absorbed after oral administration.

Distribution: Extensively distributed throughout body tissues.

Protein Binding: 98%.

Metabolism/Excretion: Extensively metabolized by the liver; one metabolite has some antidepressant activity; 14% excreted unchanged in feces.

Half-life: 24 hr.

Time/Action Profile

(antidepressant effect)

ROUTEONSETPEAKDURATION
POwithin 2–4 wkunknownunknown

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: chest pain, palpitations, QT interval prolongation, TORSADES DE POINTES.

Derm: sweating, hot flashes, rash.

EENT: pharyngitis, rhinitis, tinnitus, visual abnormalities.

Endo: diabetes, SIADH.

F and E: thirst, hyponatremia.

GI: diarrhea, dry mouth, nausea, abdominal pain, altered taste, anorexia, constipation, dyspepsia, flatulence, vomiting.

GU: libido, delayed/absent orgasm, ejaculatory delay/failure, erectile dysfunction, menstrual disorders, urinary disorders, urinary frequency.

Hemat: BLEEDING.

Metab: appetite.

MS: back pain, myalgia.

Neuro: dizziness, drowsiness, fatigue, headache, insomnia, tremor, agitation, anxiety, confusion, emotional lability, hypertonia, hypoesthesia, impaired concentration, manic reaction, nervousness, paresthesia, SUICIDAL THOUGHTS, twitching, weakness, yawning.
Misc: fever.

Interactions

Drug-Drug:

Drug-Natural Products:

Route/Dosage

Depression

Obsessive Compulsive Disorder

Panic Disorder

Post-Traumatic Stress Disorder

Social Anxiety Disorder

Premenstrual Dysphoric Disorder

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Zoloft

Pill Image

sertraline_195_9196.jpg