Therapeutic Classification: antidiarrheals
Pharmacologic Classification: tryptophan hydroxylase inhibitors
REMS
Absorption: Absorption ↑ with food (especially high-fat meal).
Distribution: Unknown.
Protein Binding: >99%.
Half-Life: Telotristat ethyl: 0.6 hr; telotristat: 5 hr.
(plasma concentrations)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
PO | unknown | 0.52 hr (telotristat ethyl); 13 hr (telotristat) | 8 hr |
Contraindicated in:
Use Cautiously in:
CV: peripheral edema
GI: nausea, abdominal pain, CONSTIPATION, ↓appetite, flatulence, ↑liver enzymes
Neuro: headache, depression
Misc: fever, HYPERSENSITIVITY REACTIONS (INCLUDING ANGIOEDEMA)
Drug-drug: