section name header

Pronunciation

nye-MOE-di-peen

Classifications

Therapeutic Classification: subarachnoid hemorrhage therapy agents

Pharmacologic Classification: calcium channel blockers

Indications

REMS


Action

  • Inhibits the transport of calcium into vascular smooth muscle cells, resulting in inhibition of excitation-contraction coupling and subsequent contraction.
  • Potent peripheral vasodilator.
Therapeutic effects:
  • Prevention of vascular spasm after subarachnoid hemorrhage, resulting in decreased neurologic impairment.

Pharmacokinetics

Absorption: Well absorbed following oral administration but undergoes first-pass metabolism, resulting in bioavailability.

Distribution: Crosses the blood-brain barrier; remainder of distribution unknown.

Protein Binding: >95%.

Metabolism/Excretion: Mostly metabolized by the liver; 10% excreted unchanged by kidneys.

Half-Life: 1–2 hr.

Time/Action Profile

(vasodilation)

ROUTEONSETPEAKDURATION
POunknown1 hr4 hr





Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: ARRHYTHMIAS, chest pain, HF, hypotension, palpitations, peripheral edema, syncope, tachycardia

Derm: sweating, dermatitis, ERYTHEMA MULTIFORME, flushing, photosensitivity, pruritus/urticaria, rash, STEVENS-JOHNSON SYNDROME (SJS)

EENT: blurred vision, disturbed equilibrium, epistaxis, tinnitus

Endo: gynecomastia, hyperglycemia

GI: liver enzymes, anorexia, constipation, diarrhea, dry mouth, dyspepsia, nausea, vomiting

GU: dysuria, nocturia, polyuria, sexual dysfunction, urinary frequency

Hemat: anemia, leukopenia, thrombocytopenia

Metab: weight

MS: joint stiffness, muscle cramps

Neuro: abnormal dreams, anxiety, confusion, dizziness, drowsiness, dysgeusia, headache, nervousness, paresthesia, psychiatric disturbances, tremor, weakness

Resp: cough, dyspnea

Misc: gingival hyperplasia

Interactions

Drug-drug:

Drug-Natural Products:

Route/Dosage

Hepatic Impairment

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Nymalize

Canadian Brand Names

Nimotop