REMS
Absorption: Well absorbed following oral administration; food enhances absorption 23-fold.
Distribution: Extensively distributed to tissues.
Protein Binding: >99%.
Half-Life: 26 hr.
Contraindicated in:
Use Cautiously in:
Derm: ↑sweating, hot flush
GU: genital/vaginal discharge
MS: muscle spasms
Neuro: STROKE
Resp: PE
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANGIOEDEMA), MALIGNANCY (BREAST, ENDOMETRIAL)
Drug-drug: