mupirocin

REMS

Treatment of:
- Impetigo,
- Secondarily infected traumatic skin lesions (up to 10 cm in length or 100 cm² area) caused by
  Staphylococcus aureus
  and
  Streptococcus pyogenes
  .

Action ⬆ ⬇

Inhibits bacterial protein synthesis.

Therapeutic effects:

Inhibition of bacterial growth and reproduction.

Spectrum:

Greatest activity against gram-positive organisms, including:
- S. aureus,
- Beta-hemolytic streptococci.
Resolution of impetigo.
Eradication of S. aureus carrier state.

Pharmacokinetics ⬆ ⬇

Absorption: Minimal systemic absorption.

Distribution: Remains in the stratum corneum after topical use for prolonged periods of time (72 hr).

Metabolism/Excretion: Metabolized in the skin, removed by desquamation.

Half-Life: 17–36 min.

Time/Action Profile ⬆ ⬇

(anti-infective effect)

ROUTE	ONSET	PEAK	DURATION
Topical‡	unknown	3–5 days	72 hr

‡Resolution of lesions.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Hypersensitivity to mupirocin or polyethylene glycol.

Use Cautiously in:

Renal impairment;
Burn patients.

Adv. Reactions/Side Effects ⬆ ⬇

Derm: burning, itching, pain, stinging

Interactions ⬆ ⬇

Drug-drug:

None reported.

Route/Dosage ⬆ ⬇

(Adults and Children ≥2 mo): Ointment: Apply 3–5 times daily for 5–14 days.
(Adults and Children ≥3 mo): Cream: Apply small amount 3 times/day for 10 days.

Availability ⬆ ⬇

(Generic available)

Cream: 2%
Ointment: 2%

Assessment ⬆ ⬇

Assess lesions before and daily during therapy.

Implementation ⬆ ⬇

Wash affected area with soap and water and dry thoroughly. Apply a small amount of mupirocin to the affected area 3 times daily and rub in gently. Treated area may be covered with gauze if desired.

Patient/Family Teaching ⬆ ⬇

Instruct patient on the correct application of mupirocin. Advise patient to apply medication exactly as directed for the full course of therapy. If a dose is missed, apply as soon as possible unless almost time for next dose. Avoid contact with eyes.
Teach patient and family appropriate hygienic measures to prevent spread of impetigo.
- Instruct parents to notify school nurse for screening and prevention of transmission.
- Patient should consult health care professional if symptoms have not improved in 3–5 days.

Evaluation/Desired Outcomes ⬆ ⬇

Healing of skin lesions. If no clinical response is seen in 3–5 days, condition should be re-evaluated.

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Pronunciation ⬇

Classifications ⬆ ⬇

Indications ⬆ ⬇