section name header

Pronunciation

da-SAti-nib

Classifications

Therapeutic Classification: antineoplastics

Pharmacologic Classification: enzyme inhibitors

Indications

High Alert

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: Well absorbed following oral administration. Absorption is pH dependent.

Distribution: Extensively distributed into extravascular space.

Protein Binding: 96%.

Metabolism/Excretion: Extensively metabolized, mostly by the CYP3A4 enzyme system. 85% eliminated in feces, mostly as metabolites; 4% eliminated in urine, mostly as metabolites.

Half-life: 3–5 hr.

Time/Action Profile

ROUTEONSETPEAKDURATION
POunknown0.5–6 hr12 hr

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: edema, HF, MI, QTc interval prolongation, hypertension, hypotension, palpitations.

Derm: rash, acne, alopecia, dry skin, ERYTHEMA MULTIFORME, flushing, nail disorder, PALMAR-PLANTAR ERYTHRODYSESTHESIA , photosensitivity, pigment disorder, STEVENS-JOHNSON SYNDROME, sweating, urticaria.

EENT: conjunctivitis, dry eye, tinnitus.

Endo: gynecomastia.

F and E: hypocalcemia.

GI: liver enzymes, diarrhea, nausea, abdominal pain, ascites, dyspepsia, ileus, mucositis, vomiting.

GU: RENAL FAILURE, urinary frequency.

Hemat: anemia, neutropenia, thrombocytopenia, BLEEDING.

Metab: growth (children), altered appetite, hyperuricemia.

MS: musculoskeletal pain, muscle inflammation/weakness.

Neuro: fatigue, headache, altered affect, anxiety, confusion, depression, drowsiness, dysgeusia, insomnia, malaise, SEIZURES, syncope, tremor, vertigo.

Resp: dyspnea, asthma, pleural effusion, pneumonitis, PULMONARY EDEMA, PULMONARY HYPERTENSION.
Misc: fever, (INCLUDING HEPATITIS B VIRUS REACTIVATION)INFECTION, TUMOR LYSIS SYNDROME.

Interactions

Drug-Drug:

Drug-Natural Products:

Drug-Food:

Route/Dosage

Accelerated, or Myeloid or Lymphoid Blast Phase Ph+ Chronic Myeloid Leukemia

Chronic Phase Ph+ Chronic Myeloid Leukemia

Ph+ Acute Lymphoblastic Leukemia

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Phyrago, Sprycel