section name header

Pronunciation

val-ay-SYE-kloe-veer

Classifications

Therapeutic Classification: antivirals

Indications

REMS


Action

  • Rapidly converted to acyclovir. Acyclovir interferes with viral DNA synthesis.
Therapeutic effects:
  • Inhibited viral replication, decreased viral shedding, reduced time to healing of lesions.
  • Reduced transmission of genital herpes.

Pharmacokinetics

Absorption: 54% bioavailable as acyclovir after oral administration of valacyclovir.

Distribution: CSF concentrations of acyclovir are 50% of plasma concentrations.

Metabolism/Excretion: Rapidly converted to acyclovir via intestinal/hepatic metabolism. Primarily excreted in the urine as acyclovir.

Half-Life: 2.5–3.3 hr; up to 14 hr in renal impairment (acyclovir).

Time/Action Profile

(plasma concentrations)
ROUTEONSETPEAKDURATION
POunknown1.5–2.5 hr8–24 hr



Acyclovir.



Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Interactions

Drug-drug:

Route/Dosage

Herpes Zoster

Renal Impairment

Genital Herpes

Renal Impairment

Herpes Labialis

Renal Impairment

Chickenpox

Availability

(Generic available)

Assessment

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Valtrex