section name header

Pronunciation

pla-zoe-MYE-sin

Classifications

Therapeutic Classification: anti-infectives

Pharmacologic Classification: aminoglycosides

Indications

REMS


Action

  • Inhibits protein synthesis in bacteria by binding to the 30S ribosome.
Therapeutic effects:
  • Bactericidal action (concentration-dependent).

Spectrum:

Pharmacokinetics

Absorption: IV administration results in complete bioavailability.

Distribution: Well distributed to tissues.

Metabolism/Excretion: Does not undergo metabolism. Primarily excreted by kidneys in urine (98% as unchanged drug).

Half-Life: 3.5 hr ( in renal impairment).

Time/Action Profile

(plasma concentrations)

ROUTEONSETPEAKDURATION
IVrapid30 min24 hr





Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Interactions

Drug-drug:

Route/Dosage

Renal Impairment

Availability

Assessment

Lab Test Considerations:

Toxicity and Overdose:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Zemdri