Malignant neoplasms of digestive organs (C15-C26)

C15Malignant neoplasm of esophagus
Use Additional Code: code to identify:
› alcohol abuse and dependence (F10.-)

C15.3Malignant neoplasm of upper third of esophagus

C15.4Malignant neoplasm of middle third of esophagus

C15.5Malignant neoplasm of lower third of esophagus
Excludes 1: malignant neoplasm of cardio-esophageal junction (C16.0)

C15.8Malignant neoplasm of overlapping sites of esophagus

C15.9Malignant neoplasm of esophagus, unspecified

C16Malignant neoplasm of stomach
Use Additional Code: code to identify:
› alcohol abuse and dependence (F10.-)
Excludes 2: malignant carcinoid tumor of the stomach (C7A.092)

C16.0Malignant neoplasm of cardia
› Malignant neoplasm of cardiac orifice
› Malignant neoplasm of cardio-esophageal junction
› Malignant neoplasm of esophagus and stomach
› Malignant neoplasm of gastro-esophageal junction

C16.1Malignant neoplasm of fundus of stomach

C16.2Malignant neoplasm of body of stomach

C16.3Malignant neoplasm of pyloric antrum
› Malignant neoplasm of gastric antrum

C16.4Malignant neoplasm of pylorus
› Malignant neoplasm of prepylorus
› Malignant neoplasm of pyloric canal

C16.5Malignant neoplasm of lesser curvature of stomach, unspecified
› Malignant neoplasm of lesser curvature of stomach, not classifiable to C16.1-C16.4

C16.6Malignant neoplasm of greater curvature of stomach, unspecified
› Malignant neoplasm of greater curvature of stomach, not classifiable to C16.0-C16.4

C16.8Malignant neoplasm of overlapping sites of stomach

C16.9Malignant neoplasm of stomach, unspecified
› Gastric cancer NOS

C17Malignant neoplasm of small intestine
Excludes 1: malignant carcinoid tumors of the small intestine (C7A.01)

C17.0Malignant neoplasm of duodenum

C17.1Malignant neoplasm of jejunum

C17.2Malignant neoplasm of ileum
Excludes 1: malignant neoplasm of ileocecal valve (C18.0)

C17.3Meckel's diverticulum, malignant
Excludes 1: Meckel's diverticulum, congenital (Q43.0)

C17.8Malignant neoplasm of overlapping sites of small intestine

C17.9Malignant neoplasm of small intestine, unspecified

C18Malignant neoplasm of colon
Excludes 1: malignant carcinoid tumors of the colon (C7A.02-)

C18.0Malignant neoplasm of cecum
› Malignant neoplasm of ileocecal valve

C18.1Malignant neoplasm of appendix

C18.2Malignant neoplasm of ascending colon

C18.3Malignant neoplasm of hepatic flexure

C18.4Malignant neoplasm of transverse colon

C18.5Malignant neoplasm of splenic flexure

C18.6Malignant neoplasm of descending colon

C18.7Malignant neoplasm of sigmoid colon
› Malignant neoplasm of sigmoid (flexure)
Excludes 1: malignant neoplasm of rectosigmoid junction (C19)

C18.8Malignant neoplasm of overlapping sites of colon

C18.9Malignant neoplasm of colon, unspecified
› Malignant neoplasm of large intestine NOS

C19Malignant neoplasm of rectosigmoid junction
› Malignant neoplasm of colon with rectum
› Malignant neoplasm of rectosigmoid (colon)
Excludes 1: malignant carcinoid tumors of the colon (C7A.02-)

C20Malignant neoplasm of rectum
› Malignant neoplasm of rectal ampulla
Excludes 1: malignant carcinoid tumor of the rectum (C7A.026)

C21Malignant neoplasm of anus and anal canal
Excludes 2: malignant carcinoid tumors of the colon (C7A.02-)
› malignant melanoma of anal margin (C43.51)
› malignant melanoma of anal skin (C43.51)
› malignant melanoma of perianal skin (C43.51)
› other and unspecified malignant neoplasm of anal margin (C44.500, C44.510, C44.520, C44.590)
› other and unspecified malignant neoplasm of anal skin (C44.500, C44.510, C44.520, C44.590)
› other and unspecified malignant neoplasm of perianal skin (C44.500, C44.510, C44.520, C44.590)

C21.0Malignant neoplasm of anus, unspecified

C21.1Malignant neoplasm of anal canal
› Malignant neoplasm of anal sphincter

C21.2Malignant neoplasm of cloacogenic zone

C21.8Malignant neoplasm of overlapping sites of rectum, anus and anal canal
› Malignant neoplasm of anorectal junction
› Malignant neoplasm of anorectum
› Primary malignant neoplasm of two or more contiguous sites of rectum, anus and anal canal

C22Malignant neoplasm of liver and intrahepatic bile ducts
Excludes 1: malignant neoplasm of biliary tract NOS (C24.9)
› secondary malignant neoplasm of liver and intrahepatic bile duct (C78.7)
Use Additional Code: code to identify:
› alcohol abuse and dependence (F10.-)
› hepatitis B (B16.-, B18.0-B18.1)
› hepatitis C (B17.1-, B18.2)

C22.0Liver cell carcinoma
› Hepatocellular carcinoma
› Hepatoma

C22.1Intrahepatic bile duct carcinoma
› Cholangiocarcinoma
Excludes 1: malignant neoplasm of hepatic duct (C24.0)

C22.2Hepatoblastoma

C22.3Angiosarcoma of liver
› Kupffer cell sarcoma

C22.4Other sarcomas of liver

C22.7Other specified carcinomas of liver

C22.8Malignant neoplasm of liver, primary, unspecified as to type

C22.9Malignant neoplasm of liver, not specified as primary or secondary

C23Malignant neoplasm of gallbladder

C24Malignant neoplasm of other and unspecified parts of biliary tract
Excludes 1: malignant neoplasm of intrahepatic bile duct (C22.1)

C24.0Malignant neoplasm of extrahepatic bile duct
› Malignant neoplasm of biliary duct or passage NOS
› Malignant neoplasm of common bile duct
› Malignant neoplasm of cystic duct
› Malignant neoplasm of hepatic duct

C24.1Malignant neoplasm of ampulla of Vater

C24.8Malignant neoplasm of overlapping sites of biliary tract
› Malignant neoplasm involving both intrahepatic and extrahepatic bile ducts
› Primary malignant neoplasm of two or more contiguous sites of biliary tract

C24.9Malignant neoplasm of biliary tract, unspecified

C25Malignant neoplasm of pancreas
Code Also: if applicable exocrine pancreatic insufficiency (K86.81)
Use Additional Code: code to identify:
› alcohol abuse and dependence (F10.-)

C25.0Malignant neoplasm of head of pancreas

C25.1Malignant neoplasm of body of pancreas

C25.2Malignant neoplasm of tail of pancreas

C25.3Malignant neoplasm of pancreatic duct

C25.4Malignant neoplasm of endocrine pancreas
› Malignant neoplasm of islets of Langerhans
Use Additional Code: code to identify any functional activity.

C25.7Malignant neoplasm of other parts of pancreas
› Malignant neoplasm of neck of pancreas

C25.8Malignant neoplasm of overlapping sites of pancreas

C25.9Malignant neoplasm of pancreas, unspecified

C26Malignant neoplasm of other and ill-defined digestive organs
Excludes 1: malignant neoplasm of peritoneum and retroperitoneum (C48.-)

C26.0Malignant neoplasm of intestinal tract, part unspecified
› Malignant neoplasm of intestine NOS

C26.1Malignant neoplasm of spleen
Excludes 1: Hodgkin lymphoma (C81.-)
› non-Hodgkin lymphoma (C82-C85)

C26.9Malignant neoplasm of ill-defined sites within the digestive system
› Malignant neoplasm of alimentary canal or tract NOS
› Malignant neoplasm of gastrointestinal tract NOS
Excludes 1: malignant neoplasm of abdominal NOS (C76.2)
› malignant neoplasm of intra-abdominal NOS (C76.2)