Other disorders of blood and blood-forming organs (D70-D77)
D70Neutropenia
Includes: agranulocytosis
› decreased absolute neurophile count (ANC)
Use Additional Code: code for any associated:
› fever (R50.81)
Code Also: , if applicable, mucositis (J34.81, K12.3-, K92.81, N76.81)
Excludes 1: neutropenic splenomegaly (D73.81)
› transient neonatal neutropenia (P61.5)
D70.0Congenital agranulocytosis
› Congenital neutropenia
› Infantile genetic agranulocytosis
› Kostmann's disease
D70.1Agranulocytosis secondary to cancer chemotherapy
Code Also: underlying neoplasm
Use Additional Code: code for adverse effect, if applicable, to identify drug (T45.1X5)
D70.2Other drug-induced agranulocytosis
Use Additional Code: code for adverse effect, if applicable, to identify drug (T36-T50) with fifth or sixth character 5)
D70.3Neutropenia due to infection
D70.4Cyclic neutropenia
› Cyclic hematopoiesis
› Periodic neutropenia
D70.8Other neutropenia
D70.9Neutropenia, unspecified
D71Functional disorders of polymorphonuclear neutrophils
D71.1Leukocyte adhesion deficiency
› LAD-I
› LAD-II
› LAD-III
› Leukocyte adhesion deficiency type I
› Leukocyte adhesion deficiency type II
› Leukocyte adhesion deficiency type III
D71.8Other functional disorders of polymorphonuclear neutrophils
› Cell membrane receptor complex [CR3] defect
› Chronic (childhood) granulomatous disease
› Congenital dysphagocytosis
› Progressive septic granulomatosis
D71.9Functional disorders of polymorphonuclear neutrophils, unspecified
D72Other disorders of white blood cells
Excludes 1: basophilia (D72.824)
› immunity disorders (D80-D89)
› preleukemia (syndrome) (D46.9)
Excludes 2: neutropenia (D70)
D72.0Genetic anomalies of leukocytes
› Alder (granulation) (granulocyte) anomaly
› Alder syndrome
› Hereditary leukocytic hypersegmentation
› Hereditary leukocytic hyposegmentation
› Hereditary leukomelanopathy
› May-Hegglin (granulation) (granulocyte) anomaly
› May-Hegglin syndrome
› Pelger-Huët (granulation) (granulocyte) anomaly
› Pelger-Huët syndrome
Excludes 1: Chédiak (-Steinbrinck)-Higashi syndrome (E70.330)
D72.1Eosinophilia
Excludes 2: Löffler's syndrome (J82.89)
› pulmonary eosinophilia (J82.-)
D72.10Eosinophilia, unspecified
D72.11Hypereosinophilic syndrome [HES]
D72.110Idiopathic hypereosinophilic syndrome [IHES]
D72.111Lymphocytic Variant Hypereosinophilic Syndrome [LHES]
› Lymphocyte variant hypereosinophilia
Code Also: , if applicable, any associated lymphocytic neoplastic disorder
D72.118Other hypereosinophilic syndrome
› Episodic angioedema with eosinophilia
› Gleich's syndrome
D72.119Hypereosinophilic syndrome [HES], unspecified
D72.12Drug rash with eosinophilia and systemic symptoms syndrome
› DRESS syndrome
Use Additional Code: code for adverse effect, if applicable, to identify drug (T36-T50) with fifth or sixth character 5)
D72.18Eosinophilia in diseases classified elsewhere
Code First: underlying disease, such as:
› chronic myelomonocytic leukemia (C93.1-)
D72.19Other eosinophilia
› Familial eosinophilia
› Hereditary eosinophilia
D72.8Other specified disorders of white blood cells
Excludes 1: leukemia (C91-C95)
D72.81Decreased white blood cell count
Excludes 2: neutropenia (D70)
D72.810Lymphocytopenia
› Decreased lymphocytes
D72.818Other decreased white blood cell count
› Basophilic leukopenia
› Eosinophilic leukopenia
› Monocytopenia
› Other decreased leukocytes
› Plasmacytopenia
D72.819Decreased white blood cell count, unspecified
› Decreased leukocytes, unspecified
› Leukocytopenia, unspecified
› Leukopenia
D72.82Elevated white blood cell count
Excludes 1: eosinophilia (D72.1)
D72.820Lymphocytosis (symptomatic)
› Elevated lymphocytes
D72.821Monocytosis (symptomatic)
Excludes 1: infectious mononucleosis (B27.-)
D72.822Plasmacytosis
D72.823Leukemoid reaction
› Basophilic leukemoid reaction
› Leukemoid reaction NOS
› Lymphocytic leukemoid reaction
› Monocytic leukemoid reaction
› Myelocytic leukemoid reaction
› Neutrophilic leukemoid reaction
D72.824Basophilia
D72.825Bandemia
› Bandemia without diagnosis of specific infection
Excludes 1: confirmed infection - code to infection
› leukemia (C91.-, C92.-, C93.-, C94.-, C95.-)
D72.828Other elevated white blood cell count
D72.829Elevated white blood cell count, unspecified
› Elevated leukocytes, unspecified
› Leukocytosis, unspecified
D72.89Other specified disorders of white blood cells
› Abnormality of white blood cells NEC
D72.9Disorder of white blood cells, unspecified
› Abnormal leukocyte differential NOS
D73Diseases of spleen
D73.0Hyposplenism
› Atrophy of spleen
Excludes 1: asplenia (congenital) (Q89.01)
› postsurgical absence of spleen (Z90.81)
D73.1Hypersplenism
Excludes 1: neutropenic splenomegaly (D73.81)
› primary splenic neutropenia (D73.81)
› splenitis, splenomegaly in late syphilis (A52.79)
› splenitis, splenomegaly in tuberculosis (A18.85)
› splenomegaly NOS (R16.1)
› splenomegaly congenital (Q89.0)
D73.2Chronic congestive splenomegaly
D73.3Abscess of spleen
D73.4Cyst of spleen
D73.5Infarction of spleen
› Splenic rupture, nontraumatic
› Torsion of spleen
Excludes 1: rupture of spleen due to Plasmodium vivax malaria (B51.0)
› traumatic rupture of spleen (S36.03-)
D73.8Other diseases of spleen
D73.81Neutropenic splenomegaly
› Werner-Schultz disease
D73.89Other diseases of spleen
› Fibrosis of spleen NOS
› Perisplenitis
› Splenitis NOS
D73.9Disease of spleen, unspecified
D74Methemoglobinemia
D74.0Congenital methemoglobinemia
› Congenital NADH-methemoglobin reductase deficiency
› Hemoglobin-M [Hb-M] disease
› Methemoglobinemia, hereditary
D74.8Other methemoglobinemias
› Acquired methemoglobinemia (with sulfhemoglobinemia)
› Toxic methemoglobinemia
D74.9Methemoglobinemia, unspecified
D75Other and unspecified diseases of blood and blood-forming organs
Excludes 2: acute lymphadenitis (L04.-)
› chronic lymphadenitis (I88.1)
› enlarged lymph nodes (R59.-)
› hypergammaglobulinemia NOS (D89.2)
› lymphadenitis NOS (I88.9)
› mesenteric lymphadenitis (acute) (chronic) (I88.0)
D75.0Familial erythrocytosis
› Benign polycythemia
› Familial polycythemia
Excludes 1: hereditary ovalocytosis (D58.1)
D75.1Secondary polycythemia
› Acquired polycythemia
› Emotional polycythemia
› Erythrocytosis NOS
› Hypoxemic polycythemia
› Nephrogenous polycythemia
› Polycythemia due to erythropoietin
› Polycythemia due to fall in plasma volume
› Polycythemia due to high altitude
› Polycythemia due to stress
› Polycythemia NOS
› Relative polycythemia
Excludes 1: polycythemia neonatorum (P61.1)
› polycythemia vera (D45)
D75.8Other specified diseases of blood and blood-forming organs
D75.81Myelofibrosis
› Myelofibrosis NOS
› Secondary myelofibrosis NOS
Code First: the underlying disorder, such as:
› malignant neoplasm of breast (C50.-)
Use Additional Code: code, if applicable, for associated therapy-related myelodysplastic syndrome (D46.-)
Use Additional Code: code for adverse effect, if applicable, to identify drug (T45.1X5)
Excludes 1: acute myelofibrosis (C94.4-)
› idiopathic myelofibrosis (D47.1)
› leukoerythroblastic anemia (D61.82)
› myelofibrosis with myeloid metaplasia (D47.4)
› myelophthisic anemia (D61.82)
› myelophthisis (D61.82)
› primary myelofibrosis (D47.1)
D75.82Heparin induced thrombocytopenia (HIT)
Use Additional Code: code, if applicable, for adverse effect of heparin (T45.515-)
D75.821Non-immune heparin-induced thrombocytopenia
› Non-immune HIT
› Type 1 heparin-induced thrombocytopenia
D75.822Immune-mediated heparin-induced thrombocytopenia
› Immune-mediated HIT
› Type 2 heparin-induced thrombocytopenia
D75.828Other heparin-induced thrombocytopenia syndrome
› Autoimmune heparin-induced thrombocytopenia syndrome
› Delayed-onset heparin-induced thrombocytopenia
› Persisting heparin-induced thrombocytopenia
D75.829Heparin-induced thrombocytopenia, unspecified
D75.83Thrombocytosis
Excludes 2: essential thrombocythemia (D47.3)
D75.838Other thrombocytosis
› Reactive thrombocytosis
› Secondary thrombocytosis
Code Also: underlying condition, if known and applicable
D75.839Thrombocytosis, unspecified
› Thrombocythemia NOS
› Thrombocytosis NOS
D75.84Other platelet-activating anti-PF4 disorders
› Spontaneous heparin-induced thrombocytopenia syndrome (without heparin exposure)
› Thrombosis with thrombocytopenia syndrome
› Vaccine-induced thrombotic thrombocytopenia
Use Additional Code: code, if applicable, for adverse effect of other viral vaccine (T50.B95-)
D75.89Other specified diseases of blood and blood-forming organs
D75.9Disease of blood and blood-forming organs, unspecified
D75.AGlucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia
Excludes 1: glucose-6-phosphate dehydrogenase (G6PD) deficiency with anemia (D55.0)
D76Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue
Excludes 1: (Abt-) Letterer-Siwe disease (C96.0)
› eosinophilic granuloma (C96.6)
› Hand-Schüller-Christian disease (C96.5)
› histiocytic medullary reticulosis (C96.9)
› histiocytic sarcoma (C96.A)
› histiocytosis X, multifocal (C96.5)
› histiocytosis X, unifocal (C96.6)
› Langerhans-cell histiocytosis, multifocal (C96.5)
› Langerhans-cell histiocytosis NOS (C96.6)
› Langerhans-cell histiocytosis, unifocal (C96.6)
› leukemic reticuloendotheliosis (C91.4-)
› lipomelanotic reticulosis (I89.8)
› malignant histiocytosis (C96.A)
› malignant reticulosis (C86.0)
› nonlipid reticuloendotheliosis (C96.0)
D76.1Hemophagocytic lymphohistiocytosis
› Familial hemophagocytic reticulosis
› Histiocytoses of mononuclear phagocytes
D76.2Hemophagocytic syndrome, infection-associated
Use Additional Code: code to identify infectious agent or disease.
D76.3Other histiocytosis syndromes
› Reticulohistiocytoma (giant-cell)
› Sinus histiocytosis with massive lymphadenopathy
› Xanthogranuloma
D77Other disorders of blood and blood-forming organs in diseases classified elsewhere
Code First: underlying disease, such as:
› amyloidosis (E85.-)
› congenital early syphilis (A50.0-)
› echinococcosis (B67.0-B67.9)
› malaria (B50.0-B54)
› schistosomiasis [bilharziasis] (B65.0-B65.9)
› vitamin C deficiency (E54)
Excludes 1: rupture of spleen due to Plasmodium vivax malaria (B51.0)
› splenitis, splenomegaly in late syphilis (A52.79)
› splenitis, splenomegaly in tuberculosis (A18.85)