Information ⬇
- Cardiopulmonary manifestations
- - Ventilation-perfusion mismatch, increased alveolar capillary permeability, increased pulmonary water content, and decreased pulmonary compliance impede oxygen exchange and lead to ARDS (progressive diffuse pulmonary infiltrates and arterial hypoxemia) in ~50% of pts.
- - Hypotension: Normal or increased cardiac output and decreased systemic vascular resistance distinguish septic shock from cardiogenic and hypovolemic shock.
- - The ejection fraction is decreased, but ventricular dilation allows maintenance of a normal stroke volume.
- Adrenal insufficiency: may be difficult to diagnose in critically ill pts
- Renal manifestations: oliguria or polyuria, azotemia, proteinuria, and renal failure due to acute tubular necrosis
- Neurologic manifestations: delirium in the acute phase, polyneuropathy with distal motor weakness in prolonged sepsis. Survivors may have long-term cognitive impairment.
- Immunosuppression: Pts may have reactivation of HSV, CMV, or VZV.
Outline ⬆