Follows 50-70% of cases of transfusion-associated and sporadic hepatitis C. Clinically mild, often waxing and waning aminotransferase elevations; mild chronic hepatitis on liver biopsy. Extrahepatic manifestations include cryoglobulinemia, porphyria cutanea tarda, membranoproliferative glomerulonephritis, and lymphocytic sialadenitis. Diagnosis confirmed by detecting anti-HCV in serum. May lead to cirrhosis in 20-25% of cases after 20 years.
| TREATMENT | ||
Chronic Hepatitis CTherapy for chronic HCV is currently stratified based on HCV genotype and the presence of treatment naïve or treatment experienced disease in addition to pt-specific factors (see Table 334-6, HPIM-20). Therapeutic options for chronic HCV have evolved rapidly such that current recommendations as established by leading expert panels should be reviewed prior to deciding on the most appropriate treatment regimen (www.hcvguidelines.org). |