Etiology

Chronic inflammation of the gallbladder; almost always associated with gallstones. Results from repeated acute/subacute cholecystitis or prolonged mechanical irritation of gallbladder wall.

Symptoms and Signs

May be asymptomatic for years, may progress to symptomatic gallbladder disease or to acute cholecystitis, or present with complications.

Laboratory

Tests are usually normal.

Imaging

Ultrasonography preferred; usually shows gallstones within a contracted gallbladder (Table 153-1 Diagnostic Evaluation of the Bile Ducts).

Differential Diagnosis

PUD, esophagitis, irritable bowel syndrome.