After completing this chapter, the reader will be able to:
1.Define terminology related to infusion medication methods and routes.
2.Discuss advantages and risks associated with IV medication administration.
3.Describe safe injection practices.
4.Identify interventions aimed at reducing risk of tubing and catheter misconnections.
5.Identify three types of drug incompatibility.
6.Describe potential consequences of drug adsorption.
7.Identify and describe the four categories of IV drug delivery.
8.Calculate a drop rate for a gravity infusion.
9.Discuss safety issues related to the use of patient-controlled analgesia.
10.Describe advantages of and indications for subcutaneous medication and fluid infusion.
11.List potential subcutaneous infusion sites.
12.Describe advantages of and indications for intraosseous medication infusion.
13.Identify sites used in intraosseous access.
14.Differentiate between the epidural and the intrathecal space.
15.List medications that may be given via an intraspinal route.
16.Identify signs and symptoms for medication-associated complications of the intraspinal infusion route.
Infusion medications may be administered by several routes that are described in this chapter. The IV route is by far the most common. Medications and solutions also may be administered via the subcutaneous (subQ) tissue. SubQ administration is a common way to administer opioid analgesics in the palliative care or hospice patient. A number of other medications and hydration fluids also may be administered subcutaneously. The intraosseous (IO) route is a quick means to vascular access in emergent care for delivery of critical care medications and fluids. The intraspinal route may be used to deliver a variety of anesthetic, analgesic, and other medications for patients in acute care and for those with longer-term needs beyond the hospital setting. There are other less common and very specialized routes used to administer chemotherapy such as the intraperitoneal route and the intra-arterial route for chemotherapy administration directly into an organ (e.g., peritoneal space, liver) (Camp-Sorrell & Matey, 2017). Because they are so specialized, they are not addressed in this text.
The nursing process is a six-step process for problem-solving to guide nursing action (see Chapter 1 for details on the steps of the nursing process). The following table focuses on nursing diagnoses, nursing outcomes classification (NOC), and nursing interventions classification (NIC) for patients with medication administration via IV and alternate modalities. Nursing diagnoses should be patient specific and outcomes and interventions individualized. The NOC and NIC presented here are suggested directions for development of specific outcomes and interventions.
Nursing Diagnoses Related to Infusion Medication Administration | Nursing Outcomes Classification (NOC) | Nursing Interventions Classification (NIC) |
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Anxiety (mild, moderate, or severe) related to: Unfamiliar situation, stressors (new equipment technology); role function; environment | Anxiety level, anxiety self-control, coping | Anxiety reduction; calming technique; coping enhancement |
Impaired physical mobility related to: Movement limitations due to presence of VAD/infusion administration | Ambulation; mobility | Ambulation; joint mobility; positioning |
Injury, risk for related to: Physical barrier (e.g., IV tubing attached to infusion pump/pole) | Personal safety behavior Safe home environment Knowledge: Fall prevention | Health education; environmental management; fall prevention |
Risk for infection related to: Environmental exposure to pathogens; immunosuppression, invasive procedures, altered skin integrity, insufficient knowledge to avoid exposure to pathogens | Risk control: Infectious process, immune status | Infection control; infection protection |
Deficient knowledge related to: Lack of exposure; unfamiliar with infusion administration procedures | Knowledge: Treatment procedures; treatment regimen | Teaching: Disease process (reasons for infusion therapy, treatment) |
Sources: Ackley et al., 2020; Herdman et al., 2021. |
Chapter Highlights
- Advantages of IV medications include the fact that they provide a direct access to the circulatory system, a route for instant drug action, a route for delivering high drug concentrations, instant drug termination if sensitivity or an adverse reaction occurs, and a route of administration in patients in whom use of the gastrointestinal tract is limited.
- Disadvantages and risks of IV medications include the potential for harm from errors due to immediate medication effects, drug interactions due to incompatibilities, drug adsorption, errors in compounding of medication, speed shock, and vascular access device complications such as infiltration/extravasation and phlebitis.
- Drug incompatibilities fall into three broad categories: physical, chemical, and therapeutic.
- Four main methods of IV medication administration include continuous infusion, intermittent infusion, IV push, and patient-controlled analgesia.
- The subQ route may be used to administer certain medications (e.g., opioids) and fluids (hypodermoclysis).
- IO access is indicated for emergent use in both adults and children with limited or no vascular access.
- Analgesic, anesthetic, and antispasmodic medications may be administered via intraspinal catheters for acute and chronic pain management and spasticity control for patients with neurological disorders.
- Only preservative-free medications can be delivered by the intraspinal routes.
Thinking Critically: Case StudyMrs. Robertson is recovering from an abdominal hysterectomy performed 10 hours ago and is receiving morphine via an epidural catheter. Her vital signs are blood pressure 110/80; respirations 18 per minute, and pulse 82/minute. She is complaining of severe pain, rating it at an 8/10. Case Study Questions 1.What additional assessments should be done? 2.What are potential explanations for her severe pain despite the epidural infusions? 3.What would you do?
Media Link: Chapter post tests and answers are provided on FADavis.com along with case studies and critical thinking activities.
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- AAMI Foundation (2016). Quick guide: Improving the safe use of multiple IV infusions https://www.ivenix.com/wp-content/uploads/2017/04/Infusion_Therapy_Quick_Guide-Multiple-IV-Infusions.pdf
- Ackley, B. J., Ladwig, G. B., Makic, M. B. F., Martinez-Kratz, M., & Zanotti, M. (2020). Nursing diagnosis handbook: An evidence-based guide to planning care (12th ed). Elsevier.
- Ayers, P., Bobo, E.S., Hurt, R.T., Mays, A.A., Worthington, P.H. (2020) ASPEN parenteral nutrition handbook (3rd ed.). ASPEN.
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- Camp-Sorrell, D., & Matey, L. (2017). Access device standards of practice for oncology nursing. Oncology Nursing Society.
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- Dornhofer, P., & Kellar, J. Z. (2021). Intraosseous vascular access. In StatPearls. StatPearls Publishing.
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- Elledge, C. M. (2017). Intraventricular access devices. In D.Camp-Sorrell & L.Matey (Eds.). Access device standards of practice for oncology nursing (pp. 113-117). Oncology Nursing Society.
- Elledge, C. M., & Stovall, M. (2017). Epidural and intrathecal access devices. In D.Camp-Sorrell & L.Matey (Eds.). Access device standards of practice for oncology nursing (pp. 119-129). Oncology Nursing Society.
- Emergency Nurses Association. (2018). Clinical practice guideline: Difficult intravenous access. Author.
- Faerber, J., Zhong, W., Dai, D., Baehr, A., Maxwell, L. G., Kraemer, F., W., & Feudtner, C. (2017). Comparative safety of morphine delivered via intravenous route vs. patient-controlled analgesia device for pediatric inpatients. Journal of Pain and Symptom Management, 53(5), 842-850.
- Gahart, B. L., Nazareno, A. R., & Ortega, M. Q. (2021). Intravenous medications (37th ed.). Mosby.
- Gates, P. J., Baysari, M. T., Gazarian, M., Raban, M. Z., Meyerson, S., & Westbrook, J. I. (2019). Prevalence of medication errors among paediatric inpatients: Systematic review and meta-analysis. Drug Safety, 42(11), 1329-1342. https://doi.org/10.1007/s40264-019-00850-1
- Gorski, L. A. (2020) Infusion therapy: A model for safe practice in the home setting. American Nurse Journal, 15(6), 8-11.
- Gorski, L. A., Hadaway, L., Hagle, M. E., Broadhurst, D., Clare, S., Kleidon, T., Meyer, B. M., Nickel, B., Rowley, S., Sharpe, E., & Alexander, M. (2021). Infusion therapy standards of practice, 8th edition. Journal of Infusion Nursing: The Official Publication of the Infusion Nurses Society, 44(1S Suppl. 1), S1-S224.
- Hagedorn, P. A., Kirkendall, E. S., Kouril, M., Dexheimer, J. W., Courter, J., Minich, T., & Spooner, S. A. (2017). Assessing frequency and risk of weight entry errors in pediatrics. JAMA Pediatrics, 171(4), 392-393.
- Harding, M., Stefka, S., Bailey, M., Morgan, D., & Anderson, A. (2020). Best practice for delivering small-volume intermittent intravenous infusions. Journal of Infusion Nursing, 43(1), 47-52. https://doi.org/10.1097/NAN.0000000000000355
- Herdman, T. H., Kamitsuru, S., Lopes, C. T. (2021). NANDA International Inc. nursing diagnoses definitions and classification 2020-2023 (12th ed.). Thieme.
- Institute for Safe Medication Practices (ISMP). (2008). Misprogramming PCA concentration leads to dosing errors. https://www.ismp.org/newsletters/acutecare/articles/20080828.asp
- ISMP. (2021). ISMP list of high-alert medications in community/ambulatory healthcare. https://www.ismp.org/recommendations/high-alert-medications-community-ambulatory-list
- ISMP. (2015). ISMP safe practice guidelines for adult IV push medications. Retrieved from https://www.ismp.org/Tools/guidelines/ivsummitpush/ivpushmedguidelines.pdf
- ISMP. (2016a). ISMP safety alert: Worth repeating . . . recent PCA by proxy event suggests reassessment of practices that may have fallen by the wayside. https://www.ismp.org/newsletters/acutecare/showarticle.aspx?id=1149
- ISMP. (2016b). Recommendations for the safe management of patients with an external subcutaneous insulin pump during hospitalization. https://www.ismp.org/sites/default/files/attachments/2018-05/Insulin%20Pump%20Recommendations%2010-20-2016_0.pdf
- ISMP. (2018). ISMP list of high-alert medications in acute care settings. https://www.ismp.org/recommendations/high-alert-medications-acute-list
- ISMP (2020a). ISMP Targeted medication safety best practices for hospitals: 2020. https://www.ismp.org/guidelines/best-practices-hospitals
- ISMP (2020b) NRFit: A global fit for neuraxial medication safety. https://www.ismp.org/resources/nrfit-global-fit-neuraxial-medication-safety
- ISMP. (2021). ISMP list of high-alert medications in long-term care settings. https://www.ismp.org/recommendations/high-alert-medications-long-term-care-list
- Jousi, M., Laukkanen-Nevala, P., & Nurmi, J. (2019). Analysing blood from intraosseous access: A systematic review. European Journal of Emergency Medicine, 26(2), 77-85. https://doi.org/10.1097/MEJ.0000000000000569
- Jungquist, C. R., Quinlan-Colwell, A., Vallerand, A., Carlisle, H. L., Cooney, M., Dempsey, S. J., Dunwoody, D., Maly, A., Meloche, K., Meyers, A., Sawyer, J., Singh, N., Sullivan, D., Watson, C., & Polomano, R. C. (2020). American Society for Pain Management Nursing guidelines on monitoring for opioid-induced advancing sedation and respiratory depression: Revisions. Pain Management Nursing, 21(1), 7-25. https://doi.org/10.1016/j.pmn.2019.06.007
- Koeck, J. A., Young, N. J., Kontny, U., Orlikowsky, T., Bassler, D., & Eisert, A. (2021). Interventions to Reduce Medication Dispensing, Administration, and Monitoring Errors in Pediatric Professional Healthcare Settings: A Systematic Review. Frontiers in pediatrics, 9, 633064. https://doi.org/10.3389/fped.2021.633064
- Lenz, J. R., Degnan, D. D., Hertig, J. B., & Stevenson, J. G. (2017). A review of best practices for intravenous push medication administration. Journal of Infusion Nursing, 40(6), 354-358. https://doi.org/10.1097/NAN.0000000000000247
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- Luokkamäki, S., Härkänen, M., Saano, S., & Vehviläinen-Julkunen, K. (2021). Registered nurses' medication administration skills: A systematic review. Scandinavian Journal of Caring Sciences, 35(1), 37-54. https://doi.org/10.1111/scs.12835
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PROCEDURES DISPLAY 10-1
Administration of Medication by the Direct (IV) Push: Peripheral Catheter
Equipment prepared on a general aseptic field in accordance with ANTT (Chapter 2)
Disinfectant (e.g., 70% alcohol wipes)
Two prefilled syringes of 0.9% sodium chloride
Labeled medication prepared by pharmacy in syringe
Delegation
This procedure cannot be delegated.
Procedure | Rationale |
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6.Explain procedure to patient and its expected outcome, potential adverse reactions, and signs/symptoms to report.
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7.Scan the barcodes on RN identification badge, the patient's wristband, and the drug label (if barcode system is used).
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8.Disinfect the needleless connector (intermittent administration) or the injection port of the IV administration set) with antiseptic using a scrubbing for 5-15 seconds and allow to dry. Note: If administering medication with a running IV solution, ensure that the medication is compatible with the IV solution.
| 8.Disinfects and reduces risk for intraluminal introduction of microbes. A critical step in infection prevention.
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9.Attach syringe of sodium chloride and begin to flush and then slowly aspirate for blood. Slowly flush the solution; disconnect and discard.
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11.Attach medication syringe and inject slowly over the time indicated on the syringe label or according to pharmacist; disconnect and discard. Use a timer or watch to ensure correct rate of administration.
| 11.Slow injection reduces the risk for speed shock and provides time for the nurse to observe the patient for adverse effects. Studies have indicated nurses often administer IV push medications too rapidly.
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13.Attach second syringe of sodium chloride and slowly inject the sodium chloride at the same rate as the medication was injected.
| 13.To decrease the chance of a bolus of medication. To lock the VAD after the intermittent IV push medication, positive pressure must be maintained within the lumen of the catheter during and after administration of a flush solution to prevent reflux of blood into the luer-activated systems. Follow guidelines below.
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Note: There are different types of needleless connector devices, so be sure you know which devices are used in your facility. | |
14.a. For negative- and neutral displacement devices: Flush all solution into the catheter lumen, maintain force on the syringe plunger as a clamp on the catheter or extension set is closed, and then disconnect the syringe.
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b. For positive-displacement device: Flush all solution into the catheter lumen, disconnect the syringe, and then close the catheter clamp. | |
15.Assess patient response and any side effects/adverse reactions; ensure plan is in place for ongoing monitoring.
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PROCEDURES DISPLAY 10-2
Administration of Continuous Subcutaneous Medication Infusion
Equipment prepared on a General Aseptic Field in accordance with ANTT (Chapter 2)
Transparent semipermeable membrane (TSM) dressing
Prepackaged dedicated subcutaneous set from manufacturer
Antiseptic solution (alcohol-based chlorhexidine preferred)
Sterile 10-mL syringe
Prescribed fluids or prefilled medication container or cassette
Infusion pump (medication infusion)
Delegation
This procedure can be delegated to LPN/LVN as allowed by the nurse practice act.
Procedure | Rationale |
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5.Scan the barcodes on RN identification badge, the patient's wristband, and the drug label (if barcode system is used).
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7.Explain procedure to patient and its expected outcomes, potential adverse reactions, and signs/symptoms to report.
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8.Assess skin and select insertion site with adequate subcutaneous tissue: a fat fold of at least 1 inch (2.5 cm) when thumb and forefinger are pinched together. Site selection is also based on the patient's anticipated mobility and comfort.
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Note: Avoid areas that are scarred, infected, irritated, edematous, bony, or highly vascularized. | |
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11.Perform skin antisepsis and allow to dry. (Note: If skin is visibly dirty, wash with soap and water prior to skin antisepsis.)
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12.Follow the manufacturer's labeled use and direction for access device placement; prime subQ set with 0.9% sodium chloride.
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| 15.Presence of blood may be indicative of entry into blood vessel. Remove and replace device in new site if positive blood aspirate.
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16.Secure subQ device, secure connection junctions, and apply TSM dressing over the site.
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