(sīt )

[L. situs, place]

A place, position, or location.

active s.The reactive portion of an enzyme, in which the substrate molecules fit and form temporary bonds.

affiliated clinical s.An organization, academic or nonacademic, for-profit or not-for-profit, that contracts with a university, college, or technical school to provide clinical educational opportunities for its students.

antibody combining s.The particular site on an antibody molecule to which part of an antigen links, creating an antigen-antibody reaction.

SEE: antibody; antigen; antigenic determinant.

antigen binding s.Antigenic determinant.

application s.The part of the body or of an organ where a topical treatment is applied.

binding s.The particular site on a cell surface or chemical to which other chemicals bind or attach.

cleavage s.The location on a polypeptide molecule where peptide bonds are broken down by hydrolysis.

exit s.1The location where a missile, e.g., a bullet, leaves the body.2The location on the skin where an implanted device, e.g., a surgical drain, leaves the body.3The location on the skin where applied radiation leaves the body.

implant s.The site in a jaw bone where a dental prosthesis will be or is seated.

insulin injection s.Any of the sites on the body suitable for injecting insulin Because insulin is administered at least once daily, it is important to have a plan for selecting the site. The best sites for insulin injection are in the subcutaneous tissue of the abdomen. The arms and legs can also be used, but insulin uptake from these sites is less uniform. It is advisable to map out a number of injection sites in one area, use those, and then use other sites.

port s.The site on the skin where a laparoscope or other device, e.g., subcutaneously implanted medicine reservoir, is inserted into the body. SYN: puncture site .

primary s.The tissue of origin of a metastatic tumor.

puncture s.Port site.

receptor s.The particular component of a cell surface that has the ability to react with certain molecules, e.g., proteins or a virus.

recipient s.That part of the body into which cells, organs, or tissues are implanted or transplanted.

sanctuary s.A protected site, such as the brain and the testes, where infections or cancers can thrive and evade chemotherapy.

splice s.The site on a strand of messenger RNA where the molecule can be cut and reannealed during the regulation of protein synthesis by cells.